ArticleWorld journal of experimental medicine2025
Triple probiotic combination effect on metabolic, oxidative stress, and inflammatory parameters in diabetic population: Systematic review and meta-analysis.
Article in World journal of experimental medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundDiabetes is an epidemic condition affecting people globally with a high rate of morbidity and mortality. While various pharmacological and non-pharmacological treatment options are used, diabetes is still a non-treatable condition. Constant attempts are made to identify newer therapies that could support better management of the diabetes condition and improve overall quality of life. Numerous studies have supported the potential role of probiotics therapy in the diabetes condition.
aimTo evaluate the efficacy of triple probiotic combination on glycaemic, metabolic, oxidative stress, and inflammatory parameters in the diabetic population.
methodsRandomized controlled trials evaluating the efficacy of the triple probiotic combination in diabetic patients were identified. The quality of the studies was evaluated using the PEDro scale while biasness between and within the studies was assessed using the Risk of Bias tool. Meta-analysis was conducted using RevMan software, and sensitivity analysis was performed using OpenMeta Analyst software. The study protocol was registered in PROSPERO (CRD42024530999).
resultsFive good-quality clinical trials were included. Low-to-moderate risk of bias was observed. Data from 300 participants were included (150 participants in both groups). Probiotics supplementation significantly improved glycaemic and insulin parameters (glucose level: -23.86 mg/dL; insulin level: -5.02 µIU/mL; HOMA-IR: -1.82 score; QUICKI: +0.02 score; HOMA-B: -16.30 score;
conclusionThe combination of
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