Evidence map›Paper›PMID 41523784›Full record

ArticleCase reports in ophthalmological medicine2026

Early and Pronounced PVR Reaction After Revitrectomy With Allogeneic Platelet Concentrate in Persistent Macular Hole.

Patrick C Fisel, Martin Spitzer, Aydin Özen, Christos Skevas

Abstract read
In one paragraph

Article in Case reports in ophthalmological medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Patrick C FiselDepartment of Ophthalmology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, uke.de.ORCID https://orcid.org/0009-0008-9861-3089
Martin SpitzerDepartment of Ophthalmology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, uke.de.ORCID https://orcid.org/0000-0002-4588-1767
Aydin ÖzenDepartment of Ophthalmology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, uke.de.ORCID https://orcid.org/0009-0007-6923-6440
Christos SkevasDepartment of Ophthalmology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, uke.de.ORCID https://orcid.org/0000-0002-4983-3228

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report two cases of pronounced development of proliferative vitreoretinopathy (PVR) within a few days after 23G revitrectomy with allogeneic platelet concentrate (PC) in persistent macular hole in 2023-2024. None of the cases had relevant risk factors for PVR development such as intraoperative retinal tears. Because the revitrectomy with PC was performed as a no-touch technique after a previous uncomplicated vitrectomy, it is suspected that PC was the etiological factor. Many findings from previous studies indicate that the same growth factors that are secreted by the platelets and that are thought to have a positive effect on the closure of the macular foramina were also responsible for the development of PVR. Vitrectomy with PC-usually performed with autologous PC-is considered a safe standard procedure for the treatment of large and persistent macular holes. Why such a pronounced and early PVR reaction occurred in these two cases is unclear. One possible reason could be the use of allogeneic PC in our cases. To the best of our knowledge, there are no reported cases of this kind.

Indexed as

case reportmacular holeplatelet concentrateproliferative vitreoretinopathyvitrectomy

Identifiers

PMID41523784
PMCPMC12780536

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.