Evidence map›Paper›PMID 41523934›Full record

ReviewCirculation reports2026

Effects of Protein and Amino Acid Supplementation on Physical Performance in Patients With Chronic Heart Failure　- A Systematic Review and Meta-Analysis.

Hirotada Maeda, Yasuyuki Kurasawa, Yuto Fujita, Minoru Wakasa, Takashi Kitagawa

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Circulation reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hirotada MaedaDepartment of Rehabilitation, Kanazawa Medical University Hospital Ishikawa Japan.
Yasuyuki KurasawaDepartment of Rehabilitation, Faculty of Health Sciences, Nagano University of Health and Medicine Nagano Japan.
Yuto FujitaDepartment of Rehabilitation, Kanazawa Medical University Hospital Ishikawa Japan.
Minoru WakasaDepartment of Cardiology, Kanazawa Medical University Ishikawa Japan.
Takashi KitagawaDepartment of Physical Therapy, School of Health Sciences, Shinshu University Nagano Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: This study aimed to evaluate the effects of protein and amino acid supplementation on physical performance in patients with chronic heart failure (CHF). Methods and Results: Studies from PubMed, the Cochrane Library, CINAHL, Web of Science, and PEDro published up to August 2024 were identified using a comprehensive strategy with no limitations on publication date or language. The primary outcome was physical performance, assessed using the 6-min walk distance (6MWD) test. This study included 15 randomized controlled trials involving a total of 744 patients. Control groups received either a placebo or usual care, including standard heart failure treatment. The meta-analysis demonstrated a significant improvement in 6MWD in the supplementation group compared with controls (mean difference 35.25 m; 95% confidence interval 15.93-54.58; I Conclusions: Our meta-analysis indicated that physical performance in patients with CHF was improved by using protein and amino acid supplementation, particularly in older adults or those unable to engage in adequate exercise therapy. However, the overall quality of the evidence was very low.

Indexed as

Amino acidHeart failurePhysical performanceProtein

Identifiers

PMID41523934
PMCPMC12782904

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.