Evidence map›Paper›PMID 41524173›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Metabolic Reprogramming Driven by Trophoblasts and Decidual XCR1

Meiqi Chen, Yuxiong Guo, Qing Zhao, Jingping Liu, Shuyi Kuang, Zhengcong Huang, Chenlin Lv, Shuxiu Xu, Zekai Zhuang, Anyan Yang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Meiqi ChenPediatric Intensive Care Unit, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Department of Immunology, School of Basic Medical Sciences, Department of Clinical Laboratory, The Third Affiliated Hospital of Southern Medical University, Southern Medical University, Guangzhou, China.
Yuxiong GuoPediatric Intensive Care Unit, Guangdong Provincial Cardiovascular Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University;Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Qing ZhaoDepartment of Immunology School of Basic Medical Sciences, Guangdong Provincial Key Laboratory of Single-cell and Extracellular Vesicles, Southern Medical University, Guangzhou, China.
Jingping LiuDepartment of Clinical Laboratory, The Third Affiliated Hospital of Southern Medical University, Southern Medical University, Guangzhou, China.
Shuyi KuangDepartment of Immunology School of Basic Medical Sciences, Guangdong Provincial Key Laboratory of Single-cell and Extracellular Vesicles, Southern Medical University, Guangzhou, China.
Zhengcong HuangDepartment of Immunology School of Basic Medical Sciences, Guangdong Provincial Key Laboratory of Single-cell and Extracellular Vesicles, Southern Medical University, Guangzhou, China.
Chenlin LvDepartment of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Shuxiu XuDepartment of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Zekai ZhuangDepartment of Immunology School of Basic Medical Sciences, Guangdong Provincial Key Laboratory of Single-cell and Extracellular Vesicles, Southern Medical University, Guangzhou, China.
Anyan YangDepartment of Immunology School of Basic Medical Sciences, Guangdong Provincial Key Laboratory of Single-cell and Extracellular Vesicles, Southern Medical University, Guangzhou, China.
Jing LiDepartment of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Kai WuDepartment of Pediatric Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Yumei HeDepartment of Immunology School of Basic Medical Sciences, Guangdong Provincial Key Laboratory of Single-cell and Extracellular Vesicles, Southern Medical University, Guangzhou, China.ORCID https://orcid.org/0000-0003-4745-3210

Funding

Guangdong Basic and Applied Basic Research Foundation 2022A1515140172Guangdong Basic and Applied Basic Research Foundation 2024A1515012897Guangdong Basic and Applied Basic Research Foundation 2024A1515140189National Natural Science Foundation of China 82171706National Natural Science Foundation of China 82471736Open Fund Project of Guangdong Academy of Medical Sciences YKY-KF202209
6 · The paper itself

Abstract

Trophoblast-immune cell communication is crucial during pregnancy, with impairments linked to adverse outcomes. The accumulation of decidual polymorphonuclear myeloid-derived suppressor cells (dPMN-MDSCs) in the third trimester is vital for fetal development. This study presents a novel crosstalk mechanism between trophoblasts and dPMN-MDSCs that improves adverse outcomes associated with advanced maternal age (AMA). A specific dPMN-MDSC population with high X-C motif chemokine receptor 1 (XCR1) expression is identified, which interacts with trophoblasts through X-C motif chemokine ligand 1 (XCL1) during the third trimester. Spontaneous fetal growth restriction observed in AMA and pregnant Xcr1

Indexed as

DeciduaMyeloid-Derived Suppressor CellsTrophoblastsAdvanced Maternal AgeAnimalsFemaleHumansMetabolic ReprogrammingMicePregnancyadvanced maternal ageadverse pregnancy outcomescrosstalkmetabolic reprogrammingpolymorphonuclear myeloid‐derived suppressor cells

Identifiers

PMID41524173
PMCPMC13042359

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.