Evidence map›Paper›PMID 41524227›Full record

ReviewAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Antibody-Empowered Nanomedicine for Precise Biomedical Applications.

Chen Chen, Xinglin Chen, Zhenhao Gao, Meng Sun, Yaozong Yu, Fang Lv, Qiujun Wang, Jinfeng Zhang

Abstract readReview
In one paragraph

Review in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Antibody-Empowered Nanomedicine for Precise Biomedical Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Chen ChenKey Laboratory of Molecular Medicine and Biotherapy, School of Life Science, Beijing Institute of Technology, Beijing, P. R. China.
Xinglin ChenKey Laboratory of Molecular Medicine and Biotherapy, School of Life Science, Beijing Institute of Technology, Beijing, P. R. China.
Zhenhao GaoKey Laboratory of Molecular Medicine and Biotherapy, School of Life Science, Beijing Institute of Technology, Beijing, P. R. China.
Meng SunKey Laboratory of Molecular Medicine and Biotherapy, School of Life Science, Beijing Institute of Technology, Beijing, P. R. China.
Yaozong YuDepartment of Anesthesiology, Hebei Medical University Third Hospital, Shijiazhuang, P. R. China.
Fang LvKey Laboratory of Molecular Medicine and Biotherapy, School of Life Science, Beijing Institute of Technology, Beijing, P. R. China.
Qiujun WangDepartment of Anesthesiology, Hebei Medical University Third Hospital, Shijiazhuang, P. R. China.
Jinfeng ZhangKey Laboratory of Molecular Medicine and Biotherapy, School of Life Science, Beijing Institute of Technology, Beijing, P. R. China.ORCID https://orcid.org/0000-0002-1899-888X

Funding

National Natural Science Foundation of China 32371442Natural Science Foundation of Beijing Municipality 7252289Natural Science Foundation of Hebei Province H2024206055The University-Hospital Collaborative Fund Program (Strengthening Basic Research Plan, Class A) of The Hebei Medical University Third Hospital ydsyqjjh202502
6 · The paper itself

Abstract

The advancement of nanotechnology has positioned nanomedicine as powerful tools for disease diagnosis and treatment. However, the clinical efficacy of conventional nanomedicine is often limited by its passive targeting strategies and limited range of therapeutic mechanisms, leading to suboptimal accumulation at diseased sites and compromised therapeutic outcomes. Fortunately, the incorporation of antibodies, with their unparalleled targeting specificity and immune-activating capabilities, presents a pivotal strategy to overcome these hurdles of nanoparticles. This review systematically summarizes the current progress in antibody-empowered nanomedicine. Different antibody functionalization strategies for nanoparticles, along with their respective advantages, limitations, and typical applications, are first discussed. This review then individually describes the classification of these nanomedicines based on antibody structures, such as IgG-like antibodies, antibody fragments, and novel antibody-nanomedicine fusion formats. Subsequently, a specific emphasis is placed on the highlight of their biomedical applications in diagnostics, bioimaging, and the treatment of various diseases. Finally, ongoing challenges and prospects in the clinical translation of antibody-empowered nanomedicine are critically examined. This review is intended to catalyze interdisciplinary breakthroughs that propel antibody-empowered nanomedicine as an important pillar of precision medicine.

Indexed as

AntibodiesNanomedicineNanoparticlesPrecision MedicineAnimalsHumansAntibodiesactive targetingantibodybiomedical applicationsimmunonanoparticlesprecision medicine

Identifiers

PMID41524227
PMCPMC12915164

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.