Evidence map›Paper›PMID 41524456›Full record

ArticleEuropean journal of immunology2026

The Increased Secretion of Lactate Observed in Obesity and Aging Leads to the Generation of Pathogenic B Cells.

Maria Romero, Amanda Virtue, Kate Miller, Andrew Gelsomini, Dhananjay Suresh, Sophie LaPointe, Suresh Pallikkuth, Daniela Frasca

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Maria RomeroDepartment of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, Florida, USA.
Amanda VirtueDepartment of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, Florida, USA.
Kate MillerDepartment of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, Florida, USA.
Andrew GelsominiDepartment of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, Florida, USA.
Dhananjay SureshDepartment of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, Florida, USA.
Sophie LaPointeDepartment of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, Florida, USA.
Suresh PallikkuthDepartment of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, Florida, USA.
Daniela FrascaDepartment of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, Florida, USA.ORCID 0000-0002-9816-6679

Funding

Tumor Biology Research ProgramP30CA240139 · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · 2025 to 2025
$3.0M
Metabolic deficits and immune dysfunction in aging people living with HIVR01AG086071 · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · 2025 to 2025
$607k
NCI NIH HHS P30 CA240139NIA NIH HHS R01 AG086071NIA NIH HHS R56 AG059719
6 · The paper itself

Abstract

Lactate is a metabolite with immunoregulatory functions. We evaluated lactate secretion and its effects on B cells from individuals with different body composition: Y

Indexed as

AgingB-LymphocytesLactic AcidObesityHumansSTAT3 Transcription FactorLactic AcidSTAT3 protein, humanSTAT3 Transcription FactoragingB cellslactateobesity

Identifiers

PMID41524456
PMCPMC12794754

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.