Evidence map›Paper›PMID 41524499›Full record

ReviewJournal of bacteriology2026

Chemical-mediated alteration of antibiotic susceptibility: mechanisms and potential new targets for antibiotic adjuvant discovery.

Joshua M E Adams, Omar M El-Halfawy

Abstract readReview
In one paragraph

Review in Journal of bacteriology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Joshua M E AdamsDepartment of Chemistry and Biochemistry, Faculty of Science, University of Regina, Regina, Saskatchewan, Canada.ORCID 0009-0005-9630-7430
Omar M El-HalfawyDepartment of Chemistry and Biochemistry, Faculty of Science, University of Regina, Regina, Saskatchewan, Canada.ORCID 0000-0003-2829-5851

Funding

Canada Research Chairs CRC-2024-00304CIHR 196079CIHR Strategic Master's ScholarshipCystic Fibrosis Canada 1191374Natural Sciences and Engineering Research Council of Canada DGECR-2022-00206Natural Sciences and Engineering Research Council of Canada RGPIN-2022-04239New Frontiers in Research Funds NFRFE-2021-00398Saskatchewan Health Research Foundation 6115
6 · The paper itself

Abstract

The critical rise in antimicrobial resistance rates, coupled with a nearly stagnant drug discovery pipeline, has resulted in a sharp surge in clinical failure of antibiotic therapy. Antimicrobial resistance, possibly leading to therapeutic failures, has been predominantly attributed to genetically encoded intrinsic or acquired resistance determinants. However, small molecules that bacteria may be exposed to at the infection site have been implicated in antibiotic resistance, tolerance, and persister formation. Such chemicals, either produced by the host or bacteria, typically elicit transient effects on antibiotic responses while bacteria are exposed to them; as such, their effects may alter therapeutic outcomes but would not be detected in standard

Indexed as

Anti-Bacterial AgentsBacteriaDrug DiscoveryDrug Resistance, BacterialAnimalsHumansMicrobial Sensitivity TestsAnti-Bacterial Agentsantibiotic adjuvantsantimicrobial resistancechemical-mediated resistanceindolephenylacetic acidpolyaminesPseudomonas quinolone signalvolatile organic compounds

Identifiers

PMID41524499
PMCPMC12918742

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.