ArticleCNS neuroscience & therapeutics2026
Wall Shear Stress Distribution in Intracranial Atherosclerotic Disease and Associations With Vessel and Plaque Morphology.
Article in CNS neuroscience & therapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Wall Shear Stress Distribution in Intracranial Atherosclerotic Disease and Associations With Vessel and Plaque Morphology.CNS neuroscience & therapeutics · 2026Article
- Article
Corrections and comments
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Authors and funding
23 authors.
Funding
Abstract
BACKGROUND AND
aimsWall shear stress (WSS) may govern the initiation and progression of atherosclerosis. We aimed to depict WSS distribution in symptomatic, atherosclerotic M1 middle cerebral artery (MCA-M1) stenosis, and its associations with adjacent vessel and plaque geometry.
methodsPatients with symptomatic, atherosclerotic, 50%-99% MCA-M1 stenosis were analyzed. MCA-M1 vessel curve orientation and tortuosity, luminal stenosis, plaque length and longitudinal asymmetry were assessed on CT angiography (CTA). Relative WSS (rWSS) was calculated by the absolute WSS divided by mean WSS at the proximal, normal vessel segment, in a CTA-based computational fluid dynamics model. rWSS < 1.0, 1.0-3.0, and > 3.0 were respectively defined as low, normal, and high WSS; low- and high-WSS areas were measured. The vessel and plaque geometry was associated with the rWSS measures, across a plaque as a whole, and separately in upstream and downstream plaque segments divided at the stenotic throat.
resultsIn 176 patients, rWSS increased progressively along the upstream plaque segment but highly varied downstream. rWSS was lower on the inner than on the outer wall of the MCA-M1 vessel curve. Patients with ventrally (than dorsally), inferiorly (than superiorly) oriented MCA-M1 vessel curves and higher tortuosity of the affected vessel segment exhibited lower rWSS and larger low-WSS areas at the downstream plaque segment. More severe luminal stenosis and upstream dominance in the plaque were associated with higher rWSS and larger high-WSS areas in the upstream and downstream plaque segments.
conclusionsWall shear stress (WSS) distribution across symptomatic MCA-M1 stenosis was variable and strongly associated with adjacent vessel and plaque geometry, independent of systemic factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.