ArticleMedical oncology (Northwood, London, England)2026
The role of glycoproteins in autophagy and apoptosis in colorectal cancer: A scoping review.
Article in Medical oncology (Northwood, London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
4 authors.
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Abstract
Colorectal cancer (CRC) is one of the most prevalent and deadliest cancers worldwide. Despite current treatments, therapeutic resistance remains a paramount challenge. Glycoproteins play essential roles in cellular processes and have been linked to drug resistance in CRC. This scoping review aims to synthesise the existing evidence on the role of glycoproteins in regulating apoptosis and autophagy in colorectal cancer. A comprehensive search was conducted using the keywords ("Autophagy") AND ("Apoptosis ") AND ("glycoprotein" OR "glycosylated proteins") AND ("colorectal cancer" OR "colon cancer" OR "CRC") across PubMed, Web of Science, and Scopus databases on 1 May 2025 without restriction. A total of nine English-language original articles were included. The outcomes show that glycoproteins such as P-gp and MRP-1 are often overexpressed in CRC cells. Inhibition of these glycoproteins significantly reduces their expression and the proliferation of CRC cells, while also enhancing cell death via apoptosis and autophagy. Hence, regulating glycoproteins in CRC provides a novel strategy to inhibit cancer progression, offering a potential avenue to overcoming therapy resistance in CRC. However, further in vivo research is necessary to elucidate the mechanism of action of glycoproteins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.