SynthesisCardiovascular toxicology2026
Corticosteroid Use and Atrial Fibrillation: Exploring Underlying Mechanisms, FAERS Disproportionality Analysis, and a Meta-Analysis of Clinical Studies.
Synthesis in Cardiovascular toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Treatment of supraventricular arrhythmias in critical care patients with sepsis.Frontiers in cardiovascular medicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Steroids are known to have proarrhythmogenic properties, even though they have been demonstrated to lower the incidence of atrial fibrillation following heart surgery. According to the American Heart Association (AHA), this negative impact was still inconsistent. Therefore, this study aims to elucidate the association between corticosteroid usage and atrial fibrillation.This systematic review employed the keywords "corticosteroids" and "atrial fibrillation," collected from PubMed, Scopus, Web of Science, and Google Scholar. Meta-analysis was performed using a random effects model through Mantel-Haenszel analysis. Disproportionality analysis and Bayesian analysis were conducted utilizing the United States Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS) datasets. A narrative review was conducted to obtain mechanistic insights into corticosteroid-induced atrial fibrillation. The meta-analysis of 23 studies involving 679,330 individuals indicated that exogenous steroids elevated the risk of atrial fibrillation by 1.74 times (95% CI = 1.55 to 1.96, p < 0.0001). Intravenous, oral, and inhaled corticosteroids elevated the risk of atrial fibrillation by 2.02, 1.95, and 1.67 times, respectively. The risk of atrial fibrillation was elevated with the administration of corticosteroids at higher doses and for longer durations. Disproportionality analysis from FAERS indicated that some corticosteroids exhibited a significant reported odds ratio (ROR). Corticosteroids can induce mechanical and electrical remodeling of cardiomyocytes, as well as cardiomyocyte senescence, cardiac hypertrophy, hypertension, and diabetes mellitus, all of which may collectively increase susceptibility to atrial fibrillation. Corticosteroids might increase the risk of atrial fibrillation in a dose- and duration-dependent fashion. Inflammation should be regarded as a confounding factor in this conclusion.
Indexed as
Identifiers
41524853What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.