Evidence map›Paper›PMID 41525003›Full record

ArticleGeroScience2026

SOD1 deficiency drives ferroptosis-linked oxidative and reproductive aging, mitigated by ginseng root extract.

Juewon Kim, Shuichi Shibuya, Yusuke Ozawa, Yorino Sato, Kazuhiro Kawamura, Takahiko Shimizu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Juewon Kim *Department of Physiology, Konkuk University College of Medicine, 27478, Chungju, Republic of Korea. juewon@kku.ac.kr.ORCID 0000-0002-0975-7873
Shuichi Shibuya *Aging Stress Response Research Project Team, National Center for Geriatrics and Gerontology, Obu , 474-8511, Aichi, Japan.
Yusuke OzawaDepartment of Endocrinology, Hematology and Gerontology, Chiba University Graduate School of Medicine, 260-8670, Chiba, Chuo-ku, Japan.
Yorino SatoDepartments of Obstetrics and Gynecology, Juntendo University Faculty of Medicine, 113-0033, Tokyo, Bunkyo-ku, Japan.
Kazuhiro KawamuraDepartments of Obstetrics and Gynecology, Juntendo University Faculty of Medicine, 113-0033, Tokyo, Bunkyo-ku, Japan.
Takahiko ShimizuAging Stress Response Research Project Team, National Center for Geriatrics and Gerontology, Obu , 474-8511, Aichi, Japan. t-shimizu.of@juntendo.ac.jp.

Funding

Japan Society for the Promotion of Science 20H03583Japan Society for the Promotion of Science 22K19607National Center for Geriatrics and Gerontology 21-9National Center for Geriatrics and Gerontology 24-17National Center for Geriatrics and Gerontology grant number 19-50National Research Foundation of Korea RS-2024-00337732
6 · The paper itself

Abstract

Aging is accompanied by cumulative oxidative stress that promotes tissue degeneration and reproductive decline. Here, we show that deficiency of superoxide dismutase 1 (SOD1) accelerates oxidative injury and reproductive aging through a ferroptosis-linked redox imbalance, and that ginseng root extract (GR) confers protection across species. Aged hairless Sod1⁻

Indexed as

AgingFerroptosisOxidative StressPanaxPlant ExtractsReproductionSuperoxide Dismutase-1AnimalsCaenorhabditis elegansFemaleMiceMice, KnockoutPlant RootsPlant ExtractsSod1 protein, mouseSuperoxide Dismutase-1FerroptosisGinseng root extractOxidative stressReproductive agingSOD1 deficiency

Identifiers

PMID41525003
PMCPMC12972492

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.