Evidence map›Paper›PMID 41525297›Full record

ReviewPLoS neglected tropical diseases2026

Human safety of SPBN GASGAS for oral rabies vaccination of dogs.

Gowri Yale, Conrad Freuling, Andrew Gibson, Amila Gunesekera, Thomas Müller, Ryan Wallace, Ad Vos

Abstract readReview
In one paragraph

Review in PLoS neglected tropical diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Gowri YaleGlobal Rabies Program, Ceva Santé Animale, Libourne, France.ORCID https://orcid.org/0000-0002-8953-7167
Conrad FreulingInstitute for Molecular Virology and Biology, Friedrich-Loeffler-Institut, Greifswald, Germany.
Andrew GibsonMission Rabies, Worldwide Veterinary Services, Dorset, United Kingdom.
Amila GunesekeraRabies Treatment Unit, National Hospital, Colombo, Sri Lanka.
Thomas MüllerInstitute for Molecular Virology and Biology, Friedrich-Loeffler-Institut, Greifswald, Germany.
Ryan WallacePoxvirus and Rabies Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America.
Ad VosGlobal Rabies Program, Ceva Santé Animale, Libourne, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oral rabies vaccination (ORV) of dogs has been suggested as a complementary tool to injectable rabies vaccination, to access free-roaming dogs during mass dog vaccination campaigns. Stringent safety requirements have been developed and implemented for ORVs targeting wildlife and dogs. Part of the safety requirements involves conducting a risk assessment of the potential for human contact with the vaccine virus and the impact on human health. The former is predominantly determined by the bait distribution method and the latter by the safety profile of the vaccine construct. This risk assessment is focused on a commercially available ORV for dogs, SPBN GASGAS. Overall, it is concluded that although human contacts with the vaccine virus do occur infrequently, the risk of serious adverse events in humans is negligible due to the safety profile of the vaccine virus construct.

Indexed as

Dog DiseasesRabiesRabies VaccinesVaccinationAdministration, OralAnimalsDogsHumansRisk AssessmentRabies Vaccines

Identifiers

PMID41525297
PMCPMC12795385

What Socratic holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.