Evidence map›Paper›PMID 41526364›Full record

ArticleNPJ Parkinson's disease2026

Moving beyond the hospital: in-depth characterization of daily-life mobility in patients with atypical Parkinsonian disorders.

Victoria Sidoroff, Hamid Moradi, Gaëlle Prigent, Frank Jagusch, Isabelle Teckenburg, Marzieh Asalian, Nina Hergenroeder-Lenzner, Marijus Giraitis, Eva Tabea Schoenfeldt-Reichmann, Jean-Pierre Ndayisaba and 14 more

Registry-linked trialAbstract read
In one paragraph

Article in NPJ Parkinson's disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04608604 (Mobility in Atypical Parkinsonism), which is not on this map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04608604 nacompletednot on this map

Mobility in Atypical Parkinsonism: a Randomized Trial of Physiotherapy

TypeinterventionalSponsorVictoria SidoroffRan2021 to 2025Enrolled180ConditionsMultiple System Atrophy, Parkinson Variant (Disorder), Parkinson Disease, Progressive Supranuclear PalsyArmsPhysiotherapy
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Victoria Sidoroff *Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
Hamid Moradi *Machine Learning and Data Analytics Lab, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.
Gaëlle Prigent *Laboratory of Movement Analysis and Measurement, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Frank JaguschDepartment of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
Isabelle TeckenburgDepartment of Molecular Neurology, University Hospital Erlangen, Erlangen, Germany.
Marzieh AsalianMachine Learning and Data Analytics Lab, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.
Nina Hergenroeder-LenznerDepartment of Molecular Neurology, University Hospital Erlangen, Erlangen, Germany.
Marijus GiraitisUniversity of Luxembourg, Esch-sur-Alzette, Luxembourg.
Eva Tabea Schoenfeldt-ReichmannNeurology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
Jean-Pierre NdayisabaDepartment of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
Georg GoebelDepartment of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
Klaus SeppiDepartment of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
Anisoara IonescuLaboratory of Movement Analysis and Measurement, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Florian KrismerDepartment of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
David BenningerNeurology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
Juergen WinklerDepartment of Molecular Neurology, University Hospital Erlangen, Erlangen, Germany.
Bjoern M EskofierMachine Learning and Data Analytics Lab, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.
Jochen KluckenUniversity of Luxembourg, Esch-sur-Alzette, Luxembourg.
Kamiar AminianLaboratory of Movement Analysis and Measurement, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Gregor WenningDepartment of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
Stefano SapienzaUniversity of Luxembourg, Esch-sur-Alzette, Luxembourg. stefano.sapienza@uni.lu.
Heiko GassnerDepartment of Molecular Neurology, University Hospital Erlangen, Erlangen, Germany. heiko.gassner@uk-erlangen.de.
Cecilia RaccagniDepartment of Neurology, Medical University of Innsbruck, Innsbruck, Austria. cecilia.raccagni@sabes.it.
MobilityAPP Study Group

Funding

Austrian Science Fund I-4795Deutsche Forschungsgemeinschaft KL 1395/10-1 ES 434/12-1Fonds National de la Recherche Luxembourg 14146272Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 320030E_192211 / 1
6 · The paper itself

Abstract

This study evaluates mobility in patients with multiple system atrophy (MSA), progressive supranuclear palsy (PSP), and Parkinson's disease (PD) by integrating clinical assessments, instrumented gait analysis (IGA) in the hospital, and 1 week of physical activity monitoring (PAM) at home, using wearable sensors. Clinical scores provide a broad measure of disease severity but lack precision in quantifying gait impairments. IGA offers objective gait metrics under standardized conditions, identifying deficits in stride dynamics and postural control. However, these controlled assessments do not reflect real-world mobility. PAM addresses this gap by continuously tracking movement patterns and physical activity during daily-life, offering insights into how patients walk beyond clinical settings. The combination of IGA and PAM provides a more comprehensive understanding of mobility limitations, particularly in MSA and PSP, where gait and balance impairments differ from PD. This dual approach enhances patient assessment, supports personalized disease management, and improves clinical decision-making. Trial registration: ClinicalTrials.gov, NCT04608604, date of registration: 19/10/2020, first patient enrollment: 01/02/2021.

Identifiers

PMID41526364
PMCPMC12858815

What Socratic holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.