Trial reportBMC pregnancy and childbirth2026
Exercise in pregnancy and maternal cardiovascular changes.
Trial report in BMC pregnancy and childbirth, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06355375 (Exercise in Pregnancy and Risk of Postpartum Depression), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Exercise in Pregnancy and Risk of Postpartum Depression
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Authors and funding
10 authors.
Funding
Abstract
objectiveTo evaluate whether regular aerobic exercise during pregnancy reduces the risk of hypertensive disorders of pregnancy and improves maternal cardiovascular adaptation.
methodsThis was a secondary analysis of a randomized clinical trial including women with singleton gestation randomly assigned in a 1:1 ratio to an exercise group or a control group. The intervention consisted of a structured aerobic exercise program from the first trimester until 35 weeks. Echocardiographic examinations were offered between 37 and 38 weeks. The primary endpoint was the incidence of gestational hypertension. Secondary outcomes included preeclampsia and echocardiographic hemodynamic, geometric and mitral inflow indices.
resultsAmong 938 randomized participants, 54 underwent echocardiography. The incidence of gestational hypertension was lower in the exercise group compared with the control group (10.1% vs 15.1%; RR 0.56, 95% CI 0.33–0.97). Preeclampsia incidence was 2.5% and 3.5%, respectively (RR 0.71, 95% CI 0.23–2.21). In the echocardiography subgroup, exercise participants had lower systolic and diastolic blood pressure, higher stroke volume (79.7 ± 7.3 vs 74.5 ± 9.2; p = 0.02), and more favorable mitral inflow indices, including a higher E’/A’ ratio (1.29 ± 0.17 vs. 1.15 ± 0.23; p = 0.01) and reduced impaired diastolic relaxation (0% vs. 27.3%; p < 0.01).
conclusionRegular exercise during pregnancy is associated with lower risk of gestational hypertension and improved cardiovascular adaptation, supporting its role in maternal hemodynamic health.
trial registrationClinicaltrials.gov NCT06355375 (Registration Date 20240409 ).
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