Evidence map›Paper›PMID 41527128›Full record

ArticleJournal of nanobiotechnology2026

pH-responsive and dual-dynamically crosslinked metal-phenolic hydrogel for synergistic macrophage and Th17/Treg reprogramming in diabetic wounds.

Yuheng Liao, Yanzhi Zhao, Chenyan Yu, Zhenhe Zhang, Yonggang Yuan, Lizhi Ouyang, Weixian Hu, Shengming Zhang, Fawwaz Al-Smadi, Bobin Mi and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yuheng Liao *Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Avenue, Hubei, 430022, Jianghan District, Wuhan, China.
Yanzhi Zhao *Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Avenue, Hubei, 430022, Jianghan District, Wuhan, China.
Chenyan Yu *Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Avenue, Hubei, 430022, Jianghan District, Wuhan, China.
Zhenhe Zhang *Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Avenue, Hubei, 430022, Jianghan District, Wuhan, China.
Yonggang YuanDepartment of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Avenue, Hubei, 430022, Jianghan District, Wuhan, China.
Lizhi OuyangDepartment of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Avenue, Hubei, 430022, Jianghan District, Wuhan, China.
Weixian HuDepartment of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Avenue, Hubei, 430022, Jianghan District, Wuhan, China.
Shengming ZhangDepartment of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Avenue, Hubei, 430022, Jianghan District, Wuhan, China.
Fawwaz Al-SmadiDepartment of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Avenue, Hubei, 430022, Jianghan District, Wuhan, China.
Bobin MiDepartment of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Avenue, Hubei, 430022, Jianghan District, Wuhan, China. mibobin@hust.edu.cn.
Mengfei LiuDepartment of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Avenue, Hubei, 430022, Jianghan District, Wuhan, China. dr_liumengfei@icloud.com.
Hui LiDepartment of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Avenue, Hubei, 430022, Jianghan District, Wuhan, China. lihuiunion@163.com.
Guohui LiuDepartment of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Avenue, Hubei, 430022, Jianghan District, Wuhan, China. liuguohui@hust.edu.cn.

Funding

National Natural Science Foundation of China 2024YFC2510600National Natural Science Foundation of China 82272491
6 · The paper itself

Abstract

In recent years, there has been a progressive increase in the cumulative number of individuals afflicted with diabetic wounds, elevating this condition to a global public health concern of significant magnitude. The disruption of the immune microenvironment is recognized as a critical factor impeding the healing process of diabetic wounds. Nevertheless, existing research has predominantly concentrated on innate immune regulation, particularly targeting macrophages, while often overlooking adaptive immunity, which plays an equally vital role within the immune microenvironment. To address both innate and adaptive immune remodeling in diabetic wounds, the CSp-OxD@Cu

Indexed as

HydrogelsMacrophagesTh17 CellsT-Lymphocytes, RegulatoryAnimalsCopperDiabetes Mellitus, ExperimentalHydrogen-Ion ConcentrationMicePhenolsRAW 264.7 CellsSchiff BasesWound HealingCopperHydrogelsPhenolsSchiff BasesAdaptive immunityImmune regulationMetal phenolic networkSpecific immunityWound healing

Identifiers

PMID41527128
PMCPMC12888242

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.