ArticleDiabetes, obesity & metabolism2026
Change in body mass index and disease burden among people with obesity and multiple long-term conditions.
Article in Diabetes, obesity & metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Screening, Diagnosis, Evaluation, and Staging of Obesity in Adults: Standards of Care in Overweight and Obesity-2026.BMJ open diabetes research & care · 2026Review
- Change in body mass index and disease burden among people with obesity and multiple long-term conditions.Diabetes, obesity & metabolism · 2026Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
aimsObesity is a risk factor for multiple long-term conditions (MLTCs/multimorbidity). However, the impact of weight loss in people with MLTCs is unclear. We investigated the association between body mass index (BMI) change and the development of obesity-related complications (ORCs), as well as clinical and economic outcomes in individuals with obesity and MLTCs. MATERIALS AND
methodsThis cohort study included adults aged ≤70 years with BMI ≥30 kg/m
resultsA total of 618 426 individuals were included. The mean number of ORCs at index (Year 4) was 3.8 (standard deviation 1.5). HRs (95% confidence intervals) for incident ORCs were 0.96 (0.94-0.98), 0.98 (0.96-0.99) and 0.98 (0.97-0.99) for the highest to lowest BMI reductions, respectively; BMI increases were associated with HRs >1.00. Risk ratios for consultations were 0.99 (0.98-1.00), 0.99 (0.98-1.00) and 1.00 (0.99-1.00). BMI reductions were linked to lower polypharmacy rates. Both BMI decrease and increase were associated with higher HRs for mental-health conditions, hospitalisation and mortality versus stable BMI.
conclusionsWeight loss in individuals with obesity and MLTCs was linked to both favourable and adverse outcomes, highlighting the importance of personalised treatment approaches that consider outcomes beyond weight loss.
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Registered trials
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