Evidence map›Paper›PMID 41527783›Full record

ArticleJournal of Alzheimer's disease : JAD2026

Evaluating MRI correlates of lifestyle-based dementia risk reduction: Results from the AgeWell.de imaging study.

Andrea E Zülke, Frauke Beyer, Melanie Luppa, Toralf Mildner, Thomas Frese, Jochen Gensichen, Hanna Kaduszkiewicz, David Czock, Hans-Helmut König, Birgitt Wiese and 5 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Andrea E ZülkeInstitute of Social Medicine, Occupational Health and Public Health (ISAP), Medical Faculty, University of Leipzig, Leipzig, Germany.
Frauke BeyerDepartment of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
Melanie LuppaInstitute of Social Medicine, Occupational Health and Public Health (ISAP), Medical Faculty, University of Leipzig, Leipzig, Germany.
Toralf MildnerDepartment of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
Thomas FreseInstitute of General Practice and Family Medicine, Martin-Luther-University Halle-Wittenberg, Halle, Germany.
Jochen GensichenInstitute of General Practice and Family Medicine, University Hospital LMU Munich, Munich, Germany.
Hanna KaduszkiewiczInstitute of General Practice, University of Kiel, Kiel, Germany.
David CzockInternal Medicine IX - Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University Hospital, Heidelberg, Germany.
Hans-Helmut KönigDepartment of Health Economics and Health Service Research, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
Birgitt WieseMHH Information Technology - Science & Laboratory, Hannover Medical School, Hannover, Germany.
Wolfgang HoffmannGerman Centre for Neurodegenerative Diseases (DZNE), site Rostock/Greifswald, Greifswald, Germany.
Jochen René ThyrianGerman Centre for Neurodegenerative Diseases (DZNE), site Rostock/Greifswald, Greifswald, Germany.
Arno VillringerDepartment of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
Steffi G Riedel-HellerInstitute of Social Medicine, Occupational Health and Public Health (ISAP), Medical Faculty, University of Leipzig, Leipzig, Germany.
A Veronica WitteDepartment of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BackgroundMultidomain lifestyle interventions can improve dementia risk by risk factor modification. Little is known about possible mechanisms underlying this effect.ObjectiveAnalyze whether changes in a validated dementia risk score were linked to changes in neuroimaging markers in a sample of older adults at increased dementia risk, participating in a multimodal lifestyle intervention.MethodsParticipants of the multi-centric AgeWell.de-trial at the Leipzig study site were examined using 3 Tesla MRI at baseline and 24-months follow-up, assessing markers of hippocampal-limbic atrophy and vascular pathology (hippocampal volume (HCV), entorhinal cortex thickness, free water fraction, peak width of skeletonized mean diffusivity, white matter hyperintensity volume, mean gray matter cerebral blood flow). Dementia risk was assessed using the Lifestyle for Brain Health (LIBRA)-index. Multivariable linear regression analyses assessed effects of changes in LIBRA on neuroimaging markers.ResultsOf 56 participants at baseline, 41 underwent the follow-up assessment (M

Indexed as

BrainDementiaLife StyleMagnetic Resonance ImagingRisk Reduction BehaviorAgedAged, 80 and overFemaleFollow-Up StudiesHumansMaleMiddle AgedRisk FactorsAlzheimer’s diseasedementialifestyleneuroimagingpreventionrisk factors

Identifiers

PMID41527783
PMCPMC12960767

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.