Evidence map›Paper›PMID 41528432›Full record

ArticleCellular and molecular life sciences : CMLS2026

The pathway-independent positive allosteric modulator C1 allows for the identification of active Y

Corinna Schüß, Oanh Vu, Tim Pelczyk, Mario Schubert, Yu Du, Jan Stichel, C David Weaver, Jens Meiler, Annette G Beck-Sickinger

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Corinna SchüßInstitute of Biochemistry, Leipzig University, 04103, Leipzig, Germany. corinna.schuess@uni-leipzig.de.ORCID http://orcid.org/0000-0002-2689-0609
Oanh VuDepartment of Chemistry, Vanderbilt University, Nashville, TN, 37235, USA.ORCID http://orcid.org/0000-0003-4704-7538
Tim PelczykInstitute of Biochemistry, Leipzig University, 04103, Leipzig, Germany.ORCID http://orcid.org/0009-0004-9374-8428
Mario SchubertInstitute of Biochemistry, Leipzig University, 04103, Leipzig, Germany.ORCID http://orcid.org/0000-0002-8375-8233
Yu DuDepartment of Pharmacology, Vanderbilt University, Nashville, TN, 37232, USA.
Jan StichelInstitute of Biochemistry, Leipzig University, 04103, Leipzig, Germany.
C David WeaverDepartment of Pharmacology, Vanderbilt University, Nashville, TN, 37232, USA.ORCID http://orcid.org/0000-0002-6886-1195
Jens MeilerDepartment of Chemistry, Vanderbilt University, Nashville, TN, 37235, USA.ORCID http://orcid.org/0000-0001-8945-193X
Annette G Beck-SickingerInstitute of Biochemistry, Leipzig University, 04103, Leipzig, Germany.ORCID http://orcid.org/0000-0003-4560-8020

Funding

NIDA NIH HHS R01 DA046138NIH HHS S10 OD016216NIH HHS S10 OD020154NIH HHS S10 OD032234
6 · The paper itself

Abstract

The neuropeptide Y

Indexed as

Receptors, Neuropeptide YAllosteric RegulationAnimalsGTP-Binding ProteinsHEK293 CellsHumansLigandsMolecular Docking SimulationNeuropeptide YPancreatic PolypeptidePeptide YYProtein BindingSignal TransductionGTP-Binding ProteinsLigandsNeuropeptide Yneuropeptide Y4 receptorPancreatic PolypeptidePeptide YYReceptors, Neuropeptide YAllosteryGPCR modulationMutagenesisNeuropeptide Y4 receptorPancreatic polypeptideReceptor pharmacology

Identifiers

PMID41528432
PMCPMC12858701

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.