Evidence map›Paper›PMID 41528518›Full record

ArticleJournal of neurology2026

Preferential age-related striatal volume preservation in cervical dystonia.

M Owusu-Ansah, A E Morris, A Tanenbaum, N L Goldman, A M Eid, S Grossen, M C Campbell, J S Perlmutter, A Z Snyder, S A Norris

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

M Owusu-AnsahDepartment of Neurology, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8111, St. Louis, MO, 63110, USA.
A E MorrisDepartment of Neurology, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8111, St. Louis, MO, 63110, USA.
A TanenbaumDepartment of Neurology, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8111, St. Louis, MO, 63110, USA.
N L GoldmanDepartment of Neurology, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8111, St. Louis, MO, 63110, USA.
A M EidDepartment of Neurology, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8111, St. Louis, MO, 63110, USA.
S GrossenDepartment of Neurology, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8111, St. Louis, MO, 63110, USA.
M C CampbellDepartment of Neurology, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8111, St. Louis, MO, 63110, USA.
J S PerlmutterDepartment of Neurology, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8111, St. Louis, MO, 63110, USA.
A Z SnyderDepartment of Radiology, Washington University in St. Louis, St. Louis, MO, USA.
S A NorrisDepartment of Neurology, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8111, St. Louis, MO, 63110, USA. norriss@wustl.edu.ORCID http://orcid.org/0000-0002-3835-0976

Funding

INVESTIGATIONS OF DEMENTIA IN PARKINSON DISEASER01NS075321 · NINDS · WASHINGTON UNIVERSITY · PI CAMPBELL, MEGHAN C, PERLMUTTER, JOEL SYNES · 2011 to 2021
$8.2M
Parkinson Disease Clinical Subtypes: Validation, Clinical Utility, and Biological CorrelatesR01NS097437 · NINDS · WASHINGTON UNIVERSITY · PI MEGHAN C CAMPBELL · 2017 to 2026
$4.1M
The Role of Striatal Cholinergic Interneurons in DystoniaR01NS124789 · NINDS · WASHINGTON UNIVERSITY · PI Scott Allen Norris · 2022 to 2026
$3.0M
Precision mapping of Parkinson's Disease pathophysiology in the Somato-Cognitive Action Network’s DBS targetsR01NS140256 · NINDS · WASHINGTON UNIVERSITY · PI Nico Dosenbach, Evan M. Gordon · 2025 to 2026
$1.2M
Washington University Physician Neuroscientist Training Pipeline (PNTP) PathwayUE5NS090978 · NINDS · WASHINGTON UNIVERSITY · PI David H Gutmann, GREGORY J ZIPFEL · 2024 to 2026
$941k
NIH HHS NIA-NINDS R01NS075321NIH HHS NINDS R01NS097437NIH HHS NS124789NINDS NIH HHS R01 NS075321NINDS NIH HHS R01 NS097437NINDS NIH HHS R01 NS124789NINDS NIH HHS R01 NS140256NINDS NIH HHS UE5 NS090978
6 · The paper itself

Abstract

background and purposePrevious research has shown inconsistent striatal volumetric differences in isolated, idiopathic dystonia. In healthy populations, progressive striatal volume loss occurs with advancing age. We investigated age-related striatal volume in participants with adult-onset cervical dystonia (CD) and other isolated, idiopathic focal dystonias.

methodsHigh-resolution structural MRI was analyzed in 184 participants (92 focal dystonia: 33 CD, 18 laryngeal, 18 blepharospasm, 10 embouchure, 13 upper-limb; 92 healthy controls). Subcortical volumes (caudate, putamen, hippocampus, amygdala, ventricles) were quantified using FreeSurfer, adjusted for intracranial volume. Linear regression examined age-volume relationships controlling for sex and motion.

resultsCD showed significantly different age-related striatal trajectories versus controls. Putamen [F(1117) = 10.82, p = 0.001, η

conclusionsOur findings reveal selective preservation of caudate and putamen volume with age that is unique to CD among focal dystonia subtypes. This neuroanatomical distinction suggests different adaptive or pathophysiological mechanisms underlying CD. These results contribute to the conceptualization of both common and heterogeneous neurobiological substrates across dystonia subtypes, highlighting the importance of subtype-specific research approaches to consider age.

Indexed as

AgingCorpus StriatumDystonic DisordersTorticollisAdultAgedFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedOrgan SizeAgingCaudateCervical dystoniaNeuroplasticityPutamenStructural MRI

Identifiers

PMID41528518
PMCPMC13185566

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.