Evidence map›Paper›PMID 41528566›Full record

ReviewCurrent atherosclerosis reports2026

Mechanistic Insight into PVAT Browning as a Protective Factor in Thoracic Aortic Aneurysm.

Wenjuan Mu, Zhenguo Wang, Y Eugene Chen, Lin Chang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current atherosclerosis reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Wenjuan MuDepartment of Internal Medicine, Cardiovascular Center, University of Michigan Medical Center, Ann Arbor, MI, 48109, USA.
Zhenguo WangDepartment of Internal Medicine, Cardiovascular Center, University of Michigan Medical Center, Ann Arbor, MI, 48109, USA.
Y Eugene ChenDepartment of Internal Medicine, Cardiovascular Center, University of Michigan Medical Center, Ann Arbor, MI, 48109, USA. echenum@umich.edu.
Lin ChangDepartment of Internal Medicine, Cardiovascular Center, University of Michigan Medical Center, Ann Arbor, MI, 48109, USA. lincha@umich.edu.

Funding

Browning of perivascular adipose tissue protects against thoracic aortic aneurysmR01HL159871 · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2025 to 2025
$586k
Browning of perivascular adipose tissue protects against thoracic aortic aneurysm HL159871NHLBI NIH HHS R01 HL151524NHLBI NIH HHS R01 HL159871PRDM16-mediated browning in perivascular adipose tissue inhibits thoracic aortic aneurysm by repressing resistin 24POST1188695Smooth muscle cell PRDM16 and aortic aneurysm HL151524The role of PRDM16 in the sexual dimorphism of abdominal aortic aneurysm 25CDA1446568
6 · The paper itself

Abstract

purpose of reviewThis review aims to provide a comprehensive overview of emerging evidence supporting the protective effects of perivascular adipose tissue (PVAT) browning in the pathophysiology of thoracic aortic aneurysm (TAA). RECENT

findingsPVAT is increasingly recognized as an active regulator of vascular homeostasis. During cardiovascular disease (CVD), PVAT undergoes a phenotypic shift from a protective brown/beige state to a dysfunctional white phenotype, contributing to vascular remodeling. Accumulating data supports beneficial effects of PVAT browning on key mechanisms involved in TAA development, including endothelial dysfunction, vascular smooth muscle cell phenotypic switching, adventitial remodeling and PVAT phenotypic shift. Studies highlight PRDM16 as a central regulator of PVAT browning, with its deficiency promoting PVAT dysfunction, adventitial fibrosis, and TAA formation. Strategies aimed at enhancing PVAT browning represent a promising therapeutic direction. However, significant gaps remain in our understanding of human PVAT biology, its interaction with the aortic wall, and the development of specific imaging tools or biomarkers. Further research is needed to clarify PVAT's role in TAA pathophysiology and to advance browning-based interventions.

Indexed as

Adipose TissueAdipose Tissue, BrownAortic Aneurysm, ThoracicVascular RemodelingAnimalsDNA-Binding ProteinsHumansTranscription FactorsDNA-Binding ProteinsPRDM16 protein, humanTranscription FactorsDysfunctionPhenotypic swiftPVAT plasticityRemodelingTAA

Identifiers

PMID41528566
PMCPMC12799636

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.