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ArticleIndian journal of pediatrics2026

Assessment of Generative AI Chatbots for Neonatal Diagnostic Reasoning: A Comparative Concordance and Diagnosis Acceptability Analysis.

Gaurav Gupta, Somashekhar Nimbalkar, Rajesh Kumar, Poonam Singh, Himel Mondal

Abstract readComparative Study
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Article in Indian journal of pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1 · What the graph read from it

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3 · Its place in the literature

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1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Gaurav GuptaDepartment of Pediatrics, All India Institute of Medical Sciences, Guwahati, Assam, India.
Somashekhar NimbalkarDepartment of Neonatology, Pramukhswami Medical College, Bhaikaka University, Gujarat, India.
Rajesh KumarDepartment of Neonatology, Rani Hospital, Ranchi, Jharkhand, India.
Poonam SinghDepartment of Neonatology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.
Himel MondalDepartment of Physiology, All India Institute of Medical Sciences, Deoghar, Jharkhand, India. himelmkcg@gmail.com.ORCID 0000-0001-6950-5857

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo assess the concordance and diagnosis acceptability of differential diagnoses (DDs) generated by artificial intelligence (AI) chatbots compared to expert neonatology physicians.

methodsThirteen clinical cases from neonatology were developed, each with five expert-defined differential diagnoses. Seven AI chatbots (ChatGPT, Claude, Copilot, Deepseek, Gemini, Grok, Perplexity) were queried to provide their most probable diagnosis along with five DDs per case. Four neonatologists evaluated the chatbot responses. Concordance scores were assigned based on the ranking of chatbot diagnoses against expert-defined diagnoses. Diagnosis acceptability scores were based on the number of DDs deemed clinically acceptable.

resultsThere were no statistically significant differences in the concordance (P = 0.205) or diagnosis acceptability (P = 0.297) scores across the seven chatbots. Chatbots had statistically significant discrepancies when compared to hypothetical values of 5, 4.5, and 4, with none of the chatbots achieving the desired concordance score of 80%. However, in terms of diagnosis acceptability, ChatGPT, Claude, and Grok had scores similar to 90% diagnosis acceptability, while Copilot, Deepseek, Gemini, and Perplexity had 80% diagnosis acceptability.

conclusionsThere were no significant differences in concordance and diagnosis acceptability scores across the seven chatbots. While none achieved the desired concordance of 80%, several models showed near 80-90% diagnosis acceptability. Hence, integration of chatbots should be done with caution.

Indexed as

Artificial IntelligenceNeonatologyDiagnosis, DifferentialGenerative Artificial IntelligenceHumansInfant, NewbornIntelligent SystemsArtificial intelligenceChatbotsDecision support systemsDifferential diagnosisLarge language modelNeonatologyPediatrician

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.