Evidence map›Paper›PMID 41528665›Full record

ArticleMolecular neurobiology2026

Dietary Isoflavone Biochanin A Attenuates Aluminium Chloride-Induced Sporadic Alzheimer's Disease and Associated Neurobehavioral Alterations Through NRF2-HO1 Pathway Activation and NLRP3 Inflammasome Suppression.

Ankit Kumar, Debarati Rakshit, Nilotpal Saharia, Purnima Tiwari, Madhav N Mugale, Awanish Mishra

Abstract read
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Article in Molecular neurobiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ankit Kumar *Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER) - Guwahati, Sila Katamur (Halugurisuk), Changsari, Kamrup, Assam, 781101, India.
Debarati Rakshit *Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER) - Guwahati, Sila Katamur (Halugurisuk), Changsari, Kamrup, Assam, 781101, India.
Nilotpal SahariaDepartment of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research (NIPER) - Guwahati, Changsari, Kamrup, Assam, 781101, India.
Purnima TiwariDepartment of Toxicology and Experimental Medicine, CSIR - Central Drug Research Institute (CDRI), Lucknow, Uttar Pradesh, 226031, India.
Madhav N MugaleDepartment of Toxicology and Experimental Medicine, CSIR - Central Drug Research Institute (CDRI), Lucknow, Uttar Pradesh, 226031, India.
Awanish MishraDepartment of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER) - Guwahati, Sila Katamur (Halugurisuk), Changsari, Kamrup, Assam, 781101, India. awanish@niperguwahati.in.ORCID http://orcid.org/0000-0001-7863-5581

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD), a debilitating neurodegenerative disorder, currently lacks effective curative treatments. Growing evidence implicates aluminium, a widely prevalent environmental metal, in the pathogenesis of AD due to its ability to induce oxidative stress, neuroinflammation, cholinergic dysfunction, and amyloid-beta (Aβ) deposition, ultimately leading to cognitive decline. Biochanin A (BCA), a naturally occurring isoflavone, exhibits well-documented antioxidant, anti-inflammatory, and neuroprotective activities, including acetylcholinesterase (AChE) inhibition. However, its specific therapeutic potential in AD models has remained largely unexplored. This study evaluates the protective effects of BCA against aluminium chloride (AlCl

Indexed as

Alzheimer DiseaseBehavior, AnimalGenisteinHeme Oxygenase-1InflammasomesNF-E2-Related Factor 2NLR Family, Pyrin Domain-Containing 3 ProteinAluminum ChlorideAnimalsMaleMiceMice, Inbred C57BLOxidative StressSignal TransductionAluminum Chloridebiochanin AGenisteinHeme Oxygenase-1InflammasomesNfe2l2 protein, mouseNF-E2-Related Factor 2NLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mouseAluminium chlorideAlzheimer’s diseaseBiochanin ACholinergic dysfunctionNeuroinflammationOxidative stress

Identifiers

PMID41528665

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.