Evidence map›Paper›PMID 41530127›Full record

ArticleNature communications2026

Identification of a thermogenic target in the dorsal raphe nucleus for weight management in mice.

Alexandre Moura-Assis, Kaja Plucińska, David Meseguer, Aiste Baleisyte, Bandy Chen, Kyle Pellegrino, Luca Parolari, Jordan T Shaked, Keith J Page, Douglas W Barrows and 20 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Alexandre Moura-AssisLaboratory of Molecular Genetics, Howard Hughes Medical Institute, The Rockefeller University, New York, NY, USA. amoura@rockefeller.edu.ORCID http://orcid.org/0000-0003-3300-3964
Kaja Plucińska *Laboratory of Molecular Metabolism, The Rockefeller University, New York, NY, USA.
David Meseguer *Laboratory of Neurovascular Control of Homeostasis, Department of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0003-2977-4176
Aiste BaleisyteLaboratory of Molecular Genetics, Howard Hughes Medical Institute, The Rockefeller University, New York, NY, USA.
Bandy ChenLaboratory of Neurovascular Control of Homeostasis, Department of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, CT, USA.
Kyle PellegrinoLaboratory of Molecular Genetics, Howard Hughes Medical Institute, The Rockefeller University, New York, NY, USA.ORCID http://orcid.org/0000-0002-2917-9855
Luca ParolariLaboratory of Molecular Genetics, Howard Hughes Medical Institute, The Rockefeller University, New York, NY, USA.
Jordan T ShakedLaboratory of Molecular Genetics, Howard Hughes Medical Institute, The Rockefeller University, New York, NY, USA.
Keith J PageCerevance, Cambridge, CB4 0PZ, United Kingdom.
Douglas W BarrowsBioinformatics Resource Center, The Rockefeller University, New York, NY, USA.
Thomas S CarrollBioinformatics Resource Center, The Rockefeller University, New York, NY, USA.
Jose G Grajales-ReyesLaboratory of Neurovascular Control of Homeostasis, Department of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, CT, USA.
Daxiang NaLaboratory of Neurovascular Control of Homeostasis, Department of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0003-2432-5902
Amanda Rodriguez-DiazLaboratory of Neurovascular Control of Homeostasis, Department of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, CT, USA.
Jessica FurtadoLaboratory of Neurovascular Control of Homeostasis, Department of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, CT, USA.
Juan Uribe IsazaLaboratory of Neurovascular Control of Homeostasis, Department of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0003-1983-3363
Hans H SchifferTakeda Development Center Americas, San Diego, CA, USA.ORCID http://orcid.org/0009-0008-7050-0816
Yun ChenTakeda Development Center Americas, San Diego, CA, USA.
Huikai SunBoundless Bio, San Diego, CA, USA.
Nidhi KaushalBristol Myers Squibb, San Diego, CA, USA.
Holger MonenscheinNuvisan, 13353, Berlin, Germany.
Daniel F BarkerCerevance, Cambridge, CB4 0PZ, United Kingdom.ORCID http://orcid.org/0000-0003-1224-4232
María José OrtuñoDepartment of Genetics, Yale School of Medicine, New Haven, CT, USA.
Nicolas RenierLaboratoire de Plasticité Structurale, Sorbonne Université, ICM Paris Brain Institute, INSERM U1127, CNRS UMR7225, 75013, Paris, France.ORCID http://orcid.org/0000-0003-2642-4402
Paul CohenLaboratory of Molecular Metabolism, The Rockefeller University, New York, NY, USA.ORCID http://orcid.org/0000-0002-2786-8585
Mark CarltonCerevance, Cambridge, CB4 0PZ, United Kingdom.
Nathaniel HeintzLaboratory of Molecular Biology, The Rockefeller University, New York, NY, USA.
Nicola L BriceCerevance, Cambridge, CB4 0PZ, United Kingdom.
Jeffrey M FriedmanLaboratory of Molecular Genetics, Howard Hughes Medical Institute, The Rockefeller University, New York, NY, USA. friedj@rockefeller.edu.ORCID http://orcid.org/0000-0003-2152-0868
Marc SchneebergerLaboratory of Neurovascular Control of Homeostasis, Department of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, CT, USA. marc.schneebergerpane@yale.edu.ORCID http://orcid.org/0000-0001-7369-104X

Funding

INTERDEPARTMENTAL NEUROSCIENCE PROGRAMT32NS041228 · YALE UNIVERSITY · 2001 to 2025
$2.5M
NIDDK NIH HHS R00 DK120869NINDS NIH HHS T32 NS041228
6 · The paper itself

Abstract

Obesity emerges from a complex interplay of factors, including imbalanced interoception, genetic predisposition, and environmental cues, which ultimately disrupt body weight homeostasis

Indexed as

Dorsal Raphe NucleusObesityThermogenesisAdipose Tissue, BrownAnimalsBody WeightDiet, High-FatEnergy MetabolismGABAergic NeuronsHumansMaleMiceMice, Inbred C57BLReceptors, G-Protein-CoupledWeight GainReceptors, G-Protein-Coupled

Identifiers

PMID41530127
PMCPMC12868712

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.