Evidence map›Paper›PMID 41530128›Full record

ArticleNature communications2026

Affiliative behaviours regulate allostasis development and shape biobehavioural trajectories in horses.

Mathilde Valenchon, Fabrice Reigner, Gaëlle Lefort, Hans Adriaensen, Amandine Gesbert, Philippe Barrière, Yvan Gaude, Frederic Elleboudt, Isabelle Lévy, Camille Ducluzeau and 9 more

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Mathilde ValenchonCNRS, INRAE, Université de Tours, UMR Physiologie de la Reproduction et des Comportements, Nouzilly, France. mathilde.valenchon@inrae.fr.ORCID 0000-0003-0226-8433
Fabrice ReignerINRAE, Unité Expérimentale de Physiologie Animale de l'Orfrasière, Centre de Recherche de Tours, Nouzilly, France.
Gaëlle LefortCNRS, INRAE, Université de Tours, UMR Physiologie de la Reproduction et des Comportements, Nouzilly, France.ORCID 0000-0001-8166-2281
Hans AdriaensenCNRS, INRAE, Université de Tours, UMR Physiologie de la Reproduction et des Comportements, Nouzilly, France.
Amandine GesbertINRAE, Unité Expérimentale de Physiologie Animale de l'Orfrasière, Centre de Recherche de Tours, Nouzilly, France.
Philippe BarrièreINRAE, Unité Expérimentale de Physiologie Animale de l'Orfrasière, Centre de Recherche de Tours, Nouzilly, France.
Yvan GaudeINRAE, Unité Expérimentale de Physiologie Animale de l'Orfrasière, Centre de Recherche de Tours, Nouzilly, France.
Frederic ElleboudtCNRS, INRAE, Université de Tours, UMR Physiologie de la Reproduction et des Comportements, Nouzilly, France.
Isabelle LévyVeterinary Clinic of the Nouvetière, La Nouvetière, Sonzay, France.
Camille DucluzeauVeterinary Clinic of the Nouvetière, La Nouvetière, Sonzay, France.
Joëlle DupontCNRS, INRAE, Université de Tours, UMR Physiologie de la Reproduction et des Comportements, Nouzilly, France.
Anne-Lyse LainéCNRS, INRAE, Université de Tours, UMR Physiologie de la Reproduction et des Comportements, Nouzilly, France.
Ivy UszynskiBAOBAB, NeuroSpin, Université Paris-Saclay, CNRS, CEA, Gif-sur-Yvette, France.ORCID 0000-0002-5249-8467
Hugues DardenteCNRS, INRAE, Université de Tours, UMR Physiologie de la Reproduction et des Comportements, Nouzilly, France.
Cyril PouponBAOBAB, NeuroSpin, Université Paris-Saclay, CNRS, CEA, Gif-sur-Yvette, France.
Léa LansadeCNRS, INRAE, Université de Tours, UMR Physiologie de la Reproduction et des Comportements, Nouzilly, France.
Ludovic CalandreauCNRS, INRAE, Université de Tours, UMR Physiologie de la Reproduction et des Comportements, Nouzilly, France.
Matthieu KellerCNRS, INRAE, Université de Tours, UMR Physiologie de la Reproduction et des Comportements, Nouzilly, France. matthieu.keller@inrae.fr.ORCID 0000-0002-5445-7431
David André BarrièreCNRS, INRAE, Université de Tours, UMR Physiologie de la Reproduction et des Comportements, Nouzilly, France. david.barriere@cnrs.fr.ORCID 0000-0003-4355-3329

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Social interactions shape both the physiological and behavioural development of offspring, and poor care/early caregiver loss is known to promote adverse outcomes during infancy in both animals and humans. How affiliative behaviours impact the future development of offspring remains an open question. Here, we used Equus caballus (domestic horse) as a model to investigate this question. By coupling magnetic resonance imaging, longitudinal biobehavioural assessments and advanced multivariate statistical modelling, we found that prolonged maternal presence during infancy promotes the maturation of brain regions involved in both social behaviour (anterior cingulate cortex and retrosplenial cortex) and physiological regulation (hypothalamus and amygdala). Additionally, offspring benefiting from a prolonged maternal presence showed higher default mode network connectivity, improved social competences and feeding behaviours, and higher concentrations of circulating lipids (triglyceride and cholesterol). The findings of the present study underscore the salient role of social interactions in the development of allostatic regulation in offspring.

Indexed as

AllostasisBehavior, AnimalSocial BehaviorAmygdalaAnimalsBrainFemaleHorsesHypothalamusMagnetic Resonance ImagingMale

Identifiers

PMID41530128
PMCPMC12800209

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.