Evidence map›Paper›PMID 41530364›Full record

ArticleScientific reports2026

Isorhamnetin inhibits mechanical stress-induced chondrocyte apoptosis through activation of the ROS/SRC/FOXO1 signaling pathway.

Jinliang Lai, Guoqiang Yin, Fanmao Zhu, Jishang Huang, Xinghua Hu, Lei Liao, Rong Wu, Jiayu Tao, Shuyue Wang, Yang Xiao and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jinliang LaiEmergency Department, Trauma Center, First Affiliated Hospital of GannanMedical University, Ganzhou, 341000, Jiangxi, China.
Guoqiang YinDepartment of Orthopedic Surgery, Ganzhou People's Hospital, Jiangxi MedicalCollege, Nanchang University, Ganzhou, 341000, Jiangxi, China.
Fanmao ZhuDepartment of Orthopedics, First Affiliated Hospital of Gannan MedicalUniversity, Ganzhou, 341000, Jiangxi, China.
Jishang HuangDepartment of Orthopedics, First Affiliated Hospital of Gannan MedicalUniversity, Ganzhou, 341000, Jiangxi, China.
Xinghua HuDepartment of Orthopedics, Xingguo People's Hospital, Ganzhou, 341000, Jiangxi, China.
Lei LiaoDingnan Second Hospital, Ganzhou, 341000, Jiangxi, China.
Rong WuGanan Medical University, Ganzhou, 341000, Jiangxi, China.
Jiayu TaoGanan Medical University, Ganzhou, 341000, Jiangxi, China.
Shuyue WangGanan Medical University, Ganzhou, 341000, Jiangxi, China.
Yang XiaoGanan Medical University, Ganzhou, 341000, Jiangxi, China.
Yiming GuGanan Medical University, Ganzhou, 341000, Jiangxi, China.
Shan LiGanan Medical University, Ganzhou, 341000, Jiangxi, China.
Jie ZhouGanan Medical University, Ganzhou, 341000, Jiangxi, China.
Yadong YangDepartment of Orthopedics, First Affiliated Hospital of Gannan MedicalUniversity, Ganzhou, 341000, Jiangxi, China. ydgogai@163.com.

Funding

Science and Technology Plan of Jiangxi Health Commission SKJP_20204484, SKJP_20195368
6 · The paper itself

Abstract

Intervertebral disc degeneration (IDD), a chronic degenerative disease, is characterized by pain without a satisfactory therapeutic strategy. Excessive mechanical pressure contributes to the pathological development of IDD by inducing chondrocyte apoptosis in the cartilage endplate. Isorhamnetin (ISO) has been shown to have chondroprotective effects by promoting chondrocyte proliferation and inhibiting chondrocyte apoptosis. In this study, we found that mechanical loading could inactivate the SRC/FOXO1 signaling pathway and increase chondrocyte apoptosis, leading to disc degeneration in rats. ISO neutralized mechanical loading-induced chondrocyte apoptosis and attenuated the progression of disc degeneration. However, activation of ROS/SRC/FOXO1 signaling by EPQpYEEIPIYL (EPQ) and H2O2 attenuated the biological effects of ISO on mechanical loading-treated chondrocytes. Therefore, ISO may protect against mechanical loading-induced injury and inhibit chondrocyte apoptosis through the activation of the ROS/SRC/FOXO1 signaling pathway.

Indexed as

ApoptosisChondrocytesForkhead Box Protein O1QuercetinReactive Oxygen SpeciesSignal Transductionsrc-Family KinasesAnimalsIntervertebral Disc DegenerationMaleRatsRats, Sprague-DawleyStress, Mechanical3-methylquercetinForkhead Box Protein O1Foxo1 protein, ratQuercetinReactive Oxygen Speciessrc-Family KinasesApoptosisEndplate chondrocytesIntervertebral disc degenerationIsorhamnetinSRC

Identifiers

PMID41530364
PMCPMC12877011

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.