Evidence map›Paper›PMID 41530521›Full record

ArticleActa neurochirurgica2026

Electrophysiological monitoring of trigeminal nerve sensory root using sensory-masseter response for microvascular decompression in trigeminal neuralgia.

Weichao Jiang, Yin Kang, Huijuan Wan, Lihui Lin, Siqi Wu, Hongwei Zhu, Xiaohua Lin, Jiayang Liu, Guowei Tan, Zhanxiang Wang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta neurochirurgica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Weichao JiangDepartment of Neurosurgery and Department of Neuroscience, Fujian Key Laboratory of Brain Tumors Diagnosis and Precision Treatment, Xiamen Key Laboratory of Brain Center, Xiamen Neurosurgical Quality Control Center, School of Medicine, the First Affiliated Hospital of Xiamen University, Xiamen University, Xiamen, Fujian, China.
Yin KangDepartment of Neurosurgery and Department of Neuroscience, Fujian Key Laboratory of Brain Tumors Diagnosis and Precision Treatment, Xiamen Key Laboratory of Brain Center, Xiamen Neurosurgical Quality Control Center, School of Medicine, the First Affiliated Hospital of Xiamen University, Xiamen University, Xiamen, Fujian, China.
Huijuan WanDepartment of Neurology and Department of Neuroscience, School of Medicine, The First Affiliated Hospital of Xiamen University, Xiamen University, Xiamen, China.
Lihui LinDepartment of Pharmacy, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, China.
Siqi WuDepartment of Neurosurgery and Department of Neuroscience, Fujian Key Laboratory of Brain Tumors Diagnosis and Precision Treatment, Xiamen Key Laboratory of Brain Center, Xiamen Neurosurgical Quality Control Center, School of Medicine, the First Affiliated Hospital of Xiamen University, Xiamen University, Xiamen, Fujian, China.
Hongwei ZhuDepartment of Neurosurgery and Department of Neuroscience, Fujian Key Laboratory of Brain Tumors Diagnosis and Precision Treatment, Xiamen Key Laboratory of Brain Center, Xiamen Neurosurgical Quality Control Center, School of Medicine, the First Affiliated Hospital of Xiamen University, Xiamen University, Xiamen, Fujian, China.
Xiaohua LinDepartment of Anesthesiology, School of Medicine, the First Affiliated Hospital of Xiamen University, Xiamen University, Xiamen, Fujian, China.
Jiayang LiuDepartment of Ophthalmology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
Guowei TanDepartment of Neurosurgery and Department of Neuroscience, Fujian Key Laboratory of Brain Tumors Diagnosis and Precision Treatment, Xiamen Key Laboratory of Brain Center, Xiamen Neurosurgical Quality Control Center, School of Medicine, the First Affiliated Hospital of Xiamen University, Xiamen University, Xiamen, Fujian, China.
Zhanxiang Wang *Department of Neurosurgery and Department of Neuroscience, Fujian Key Laboratory of Brain Tumors Diagnosis and Precision Treatment, Xiamen Key Laboratory of Brain Center, Xiamen Neurosurgical Quality Control Center, School of Medicine, the First Affiliated Hospital of Xiamen University, Xiamen University, Xiamen, Fujian, China. wangzx@xmu.edu.cn.
Xiyao Liu *Department of Neurosurgery and Department of Neuroscience, Fujian Key Laboratory of Brain Tumors Diagnosis and Precision Treatment, Xiamen Key Laboratory of Brain Center, Xiamen Neurosurgical Quality Control Center, School of Medicine, the First Affiliated Hospital of Xiamen University, Xiamen University, Xiamen, Fujian, China. xdfysjwk@163.com.

Funding

the Natural Science Foundation of Xiamen City 3502Z20227092
6 · The paper itself

Abstract

purposeTrigeminal neuralgia (TN), a debilitating condition, is commonly treated with microvascular decompression (MVD). However, effective intraoperative neurophysiological monitoring remains challenging. This study introduces a novel electrophysiological technique using sensory-masseter response (SMR) to monitor trigeminal nerve compression during MVD.

methodsA total of 34 patients with TN underwent MVD. A concentric neurostimulator was employed to systematically deliver microcurrent stimulation to various intracranial segments of the trigeminal sensory root. We specifically probed the segment distal to the suspected neurovascular conflict (NVC) site, the actual compression point itself, and the segment central to the NVC site. Stimulation was performed at equivalent anatomical levels on both the compressed and non-compressed sides for comparison. Simultaneously, compound muscle action potentials (CMAPs) were recorded from the masseter muscle. These recorded potentials were defined as the SMR. The spatial correlation between SMR positivity and NVC was analyzed to assess its clinical utility.

resultsSMR was successfully recorded in 28 out of 34 patients (82.4%). Among these 28 SMR-positive cases, NVC was identified at the stimulation site in 24 cases, with 19 showing visible vascular indentation. The mean SMR latency was 3.30 ± 0.36 ms. The stimulation threshold required to elicit SMR was significantly lower at the NVC site (median 0.3 mA, IQR 0.2-0.4 mA) compared to the distal segment of the NVC side (p < 0.001), the non-compressed side (p < 0.001), and the central segment of the NVC side (p = 0.012). A strong association was observed between NVC and SMR positivity (p < 0.001). These findings suggest that SMR positivity correlates with NVC sites.

conclusionThis study introduces a novel electrophysiological technique SMR for localizing NVC during microvascular decompression for trigeminal neuralgia. SMR is likely mediated by focal demyelination and sensory-motor anastomoses. Although SMR demonstrates potential in assisting intraoperative localization during MVD, its clinical value requires further validation.

Indexed as

Intraoperative Neurophysiological MonitoringMasseter MuscleMicrovascular Decompression SurgeryTrigeminal NerveTrigeminal NeuralgiaAction PotentialsAdultAgedElectric StimulationFemaleHumansMaleMiddle AgedComplex action potentialCompound muscle action potentialDemyelinationIntraoperative neurophysiological monitoringMicrovascular decompressionTrigeminal neuralgia

Identifiers

PMID41530521
PMCPMC12804222

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.