Evidence map›Paper›PMID 41530543›Full record

ArticleCommunications biology2026

A compendium of chromatin interaction maps in the Giant Panda genome.

Pengliang Liu, Jiaman Zhang, Kailai Cai, Juan Wang, Hong Liu, Liang Zhang, Wei Xu, Yuliang Liu, Fujun Shen, Rong Hou and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Pengliang Liu *Chengdu Research Base of Giant Panda Breeding, The Conservation of Endangered Wildlife Key Laboratory of Sichuan Province, Chengdu, China.
Jiaman Zhang *College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, China.ORCID http://orcid.org/0009-0002-7933-7417
Kailai Cai *Chengdu Research Base of Giant Panda Breeding, The Conservation of Endangered Wildlife Key Laboratory of Sichuan Province, Chengdu, China.
Juan WangChengdu Research Base of Giant Panda Breeding, The Conservation of Endangered Wildlife Key Laboratory of Sichuan Province, Chengdu, China.
Hong LiuChengdu Research Base of Giant Panda Breeding, The Conservation of Endangered Wildlife Key Laboratory of Sichuan Province, Chengdu, China.
Liang ZhangChengdu Research Base of Giant Panda Breeding, The Conservation of Endangered Wildlife Key Laboratory of Sichuan Province, Chengdu, China.ORCID http://orcid.org/0000-0002-2792-0240
Wei XuChengdu Research Base of Giant Panda Breeding, The Conservation of Endangered Wildlife Key Laboratory of Sichuan Province, Chengdu, China.ORCID http://orcid.org/0000-0003-1693-5313
Yuliang LiuChengdu Research Base of Giant Panda Breeding, The Conservation of Endangered Wildlife Key Laboratory of Sichuan Province, Chengdu, China.
Fujun ShenChengdu Research Base of Giant Panda Breeding, The Conservation of Endangered Wildlife Key Laboratory of Sichuan Province, Chengdu, China.
Rong HouChengdu Research Base of Giant Panda Breeding, The Conservation of Endangered Wildlife Key Laboratory of Sichuan Province, Chengdu, China.
Yan LiChengdu Research Base of Giant Panda Breeding, The Conservation of Endangered Wildlife Key Laboratory of Sichuan Province, Chengdu, China. liyan@panda.org.cn.ORCID http://orcid.org/0000-0003-4537-7672

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Elucidating transcriptional regulatory mechanisms within tissues is essential for both physiological and pathological studies of giant panda. Here, we generate transcriptomic profiles and construct 3D genome maps for nine giant panda tissues. For the first time, we describe alterations in 3D genome organization among giant panda tissues, providing evidence for changes of A/B compartmentalization, variations in topologically associating domains, and rewiring of promoter-enhancer interactions. We demonstrate that many 3D genome reorganization events are tissue-specific and these structural changes are associated with tissue-specific expression of genes and tissue-relevant biological functions. Furthermore, we use these 3D genome maps to systematically interpret adaptive evolution in giant panda genome, emphasizing importance of considering the genome as a 3D configuration when dissecting potential functions of DNA sequence variation. Collectively, our study increases understanding of functional regulatory mechanisms of giant panda tissues and provides a foundational dataset for analysis of tissue-specific regulatory networks in giant panda.

Indexed as

ChromatinGenomeUrsidaeAnimalsGene Expression ProfilingPromoter Regions, GeneticChromatin

Identifiers

PMID41530543
PMCPMC12905400

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.