Evidence map›Paper›PMID 41530678›Full record

ArticleBMC genomics2026

Population structure based on whole-genome resequencing and adaptive evolutionary mechanisms of circadian entrainment in the endangered fish Percocypris pingi.

Taiming Yan, Xubin Zheng, Mengna Chang, Chunxia Li, Qipeng Fu, Long He, Ziting Tang, Zhen Wei, Yinlin Xiong, Zhi He and 1 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in BMC genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Taiming Yan *College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, Sichuan, 611130, China.
Xubin Zheng *College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, Sichuan, 611130, China.
Mengna ChangCollege of Animal Science and Technology, Sichuan Agricultural University, Chengdu, Sichuan, 611130, China.
Chunxia LiCollege of Animal Science and Technology, Sichuan Agricultural University, Chengdu, Sichuan, 611130, China.
Qipeng FuCollege of Animal Science and Technology, Sichuan Agricultural University, Chengdu, Sichuan, 611130, China.
Long HeCollege of Animal Science and Technology, Sichuan Agricultural University, Chengdu, Sichuan, 611130, China.
Ziting TangCollege of Animal Science and Technology, Sichuan Agricultural University, Chengdu, Sichuan, 611130, China.
Zhen WeiCenter for Conservation and Utilization of Rare and Endemic Fishes in Sichuan, Chengdu, Sichuan, 611200, China.
Yinlin XiongCenter for Conservation and Utilization of Rare and Endemic Fishes in Sichuan, Chengdu, Sichuan, 611200, China.
Zhi HeCollege of Animal Science and Technology, Sichuan Agricultural University, Chengdu, Sichuan, 611130, China. Zhihe@sicau.edu.cn.
Deying YangCollege of Animal Science and Technology, Sichuan Agricultural University, Chengdu, Sichuan, 611130, China. deyingyang@sicau.edu.cn.

Funding

Foundation for Innovative Research Groups of the National Natural Science Foundation of China 31972777, 31402286).
6 · The paper itself

Abstract

backgroundThe endangered fish Percocypris pingi is a national second-class protected animal in China. Comprehensive evaluation of the genetic structure according to more reliable data and exploration of effective conservation measures are urgently needed for P. pingi. In this study, the genetic diversity, population structure, and adaptive evolutionary mechanism of circadian entrainment for P. pingi were performed.

resultsOur results revealed that eight wild populations (69 samples) and nine hatchery populations (90 samples) presented relatively low genetic diversity and simple population structure on the basis of whole-genome resequencing data. Compared to other 13 populations, the Datuo (DT) and Woluo (WL) wild populations and the Jinping (JP) and Yaan (YA) hatchery populations presented relatively high genetic diversity. The Fst‒Pi and XP‒EHH sites from the population group differentiation from DT, WL, JP, and YA were screened. Several GO terms (e.g. MAP kinase activity and monoatomic ion channel activity] and KEGG pathways (e.g. aldosterone synthesis and secretion and MAPK signaling) were enriched in circadian entrainment-related signaling. Then, the multiple candidate genes, such as pkc, pkd, Ac, mapk6, ampar, rorcb, rorab1, rorab2, lamb4, and ck1[Formula: see text]/∂ were shown to be enriched in the circadian entrainment pathway. Furthermore, the expression patterns of cry1a, cry2, per2a, per1b, clock1a, clock1b, baml2a, lamb4, and rorab1 and the melatonin levels in the livers demonstrated circadian oscillation within 24 h.

conclusionsLow genetic diversity and a simple population structure of P. pingi were determined. The Wuoluo River and Litang River can be recognized as new refuges for wild P. pingi and that the JP and YA hatchery populations are needed for the sustainable conservation and utilization of resources in the Yalong River and Jinsha River. The circadian entrainment may be an important adaptive evolutionary mechanism of P. pingi. The above results can help formulate science-based breeding protocols and provide necessary genetic data for managing both captive propagation and wild population reinforcement.

Indexed as

Adaptation, PhysiologicalCircadian RhythmEndangered SpeciesEvolution, MolecularWhole Genome SequencingAnimalsGenetics, PopulationGenetic VariationCircadian entrainmentEnvironmental adaptationGenetic structureGenome-wide resequencingPercocypris pingi

Identifiers

PMID41530678
PMCPMC12888270

What Socratic holds

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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.