ArticleJournal of nanobiotechnology2026
Schwann cell-derived extracellular vesicles inhibit osteoclastogenesis through the PTEN/AKT axis in peripheral nerve-bone crosstalk.
Article in Journal of nanobiotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- The miR-212-3p/transferrin axis promotes bone regeneration by modulating iron homeostasis through Schwann cell Exosome-BMSCs communication.Bioactive materials · 2026Article
- Schwann Cell Mapping and Characterization in Bone of Different Embryonic Origins.bioRxiv : the preprint server for biology · 2026Article
- O-GlcNAcylation: A bridge for regulating the function of the "heart-kidney-bone axis".Biochemistry and biophysics reports · 2026Review
- The role of the neuro-immune-bone axis in osteoporosis: from bone remodeling imbalance to multi-system interactions.Frontiers in immunology · 2026Review
- Non-Bone-Derived Extracellular Vesicles in Osteoporosis: Evidence Mapping and Nanomedicine Translation.International journal of nanomedicine · 2026Review
- Extracellular vesicle-based therapeutic strategies for spinal tumors and associated nerve damage: advances, challenges, and future directions.Frontiers in cell and developmental biology · 2026Review
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
Osteoclasts, the sole bone-resorbing cells, play a central part in bone homeostasis, and their overactivation is implicated in bone diseases such as osteoporosis. Schwann cells (SCs), the primary glial cells of the peripheral nervous system, are recognized to contribute to participating in bone remodeling through interactions with osteoblasts. Nevertheless, their specific function in osteoclasts-mediated bone resorption remains to be fully elucidated. Here, we demonstrate that SCs inhibit osteoclastogenesis in bone homeostasis, primarily through extracellular vesicles (EVs)-mediated activation of PTEN, which in turn negatively regulates the PI3K/AKT signaling pathway, and consequently attenuates the bone resorption process. To promote the targeted delivery and accumulation of EVs in bone tissue, SC-derived EVs (SC-EVs) were engineered with acidic peptides. Subsequent studies in vivo revealed that EVs derived from SCs significantly mitigated bone loss in ovariectomized mice, and bone-targeted EVs exhibited superior efficacy in restoring bone mass. These findings elucidated the neural regulation of bone homeostasis and proposed that SC-EVs, as peripheral nerve-bone crosstalk, could become a novel therapeutic approach for osteoporosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.