Evidence map›Paper›PMID 41530829›Full record

ReviewMolecular cancer2026

Intratumoral microbiome: the double-edged sword in remodeling cancer immunotherapy.

Di Yan, Ying Yu, Chengtong Liang, Zixing Cui, Lei Shi, Guiling Li, Chuanli Ren

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Molecular cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Fusobacterium nucleatum, succinate signaling, and immunotherapy resistance in colorectal cancer: clinical relevance and translational opportunities.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Di Yan *Department of Laboratory Medicine, Medical College, Yangzhou University, Yangzhou, China.
Ying Yu *Department of Laboratory Medicine, Medical College, Yangzhou University, Yangzhou, China.
Chengtong Liang *Department of Laboratory Medicine, Medical College, Yangzhou University, Yangzhou, China.
Zixing Cui *Department of Laboratory Medicine, Medical College, Yangzhou University, Yangzhou, China.
Lei Shi *Department of General Surgery, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, No. 98 Western Nantong Road, Yangzhou, 225001, China.
Guiling LiDepartment of Laboratory Medicine, Northern Jiangsu People's Hospital, Yangzhou, China. liguiling728@163.com.
Chuanli RenDepartment of Laboratory Medicine, Northern Jiangsu People's Hospital, Yangzhou, China. 18051061089@yzu.edu.cn.

Funding

Crosscooperation project of Subei Peoples' Hospital of Jiangsu Province SBJC22003National Natural Science Foundation of China 82172345Natural Science Foundation of Jiangsu Province BK20221281
6 · The paper itself

Abstract

Emerging evidence reveals that intratumoral microbial (ITM) communities within the tumor immune microenvironment (TIME) critically influence tumor progression and immunotherapy response. Studies have shown that resident bacteria within tumors, such as Sphingobacterium multivorum, regulate the secretion of chemokines like CCL20 and CXCL8, promoting the infiltration of regulatory T cells (Tregs) and inhibiting the function of cytotoxic T cells (CD8

Indexed as

Cancer immunotherapyIntratumoral microbiomeTumor immune microenvironment

Identifiers

PMID41530829
PMCPMC12934096

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.