ArticleReports of biochemistry & molecular biology2025
Therapeutic Effects of Phytoestrogen Naringenin in Polycystic Ovary Syndrome (PCOS): Involvement of Kisspeptin and Calcitonin Gene Related Peptide Signalling Pathways.
Article in Reports of biochemistry & molecular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Polycystic ovary syndrome (PCOS) is a common endocrine disorder and a major cause of infertility in women. Although studies have reported the effects of naringenin on PCOS; the underlying molecular mechanisms remain unclear. This study aimed to investigate the effect of naringenin on the expression of kisspeptin ( Methods: Twenty female rats (180-200 g) were used in this study. To PCOS induction, two mg of estradiol valerate was injected intramuscularly (IM) per rat. The control and PCOS groups received saline, while the other two groups were treated intraperitoneally with naringenin at either 20 mg/kg or 50 mg/kg, respectively. Subsequently, hypothalamic tissue was collected, and gene expression levels were analyzed using real-time PCR. Results: The expression Conclusions: Naringenin may ameliorate PCOS by downregulating hypothalamic
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