ArticleBiomedical optics express2026
Cardiac pulse transfer along the cerebral microvascular network captured by laser speckle contrast imaging.
Article in Biomedical optics express, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Optics and the Brain: introduction to the feature issue.Biomedical optics express · 2026Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Detecting subtle alterations in cardiac pulse transmission through the cerebral microvascular network could provide a new avenue for characterising cerebral microvascular health and aid in the research and diagnosis of related neurological pathologies. We used laser speckle contrast imaging to quantify the pulse waveform in cerebral microvasculature in awake and anaesthetised mice. Pulse amplitude was attenuated more efficiently in awake mice, with venular pulsatility index 63% lower than arterial, compared to a 9% and 30% reduction under isoflurane and ketamine-xylazine, respectively. Arterial-to-venous delay was similar when awake and under isoflurane (5.3±1.6 and 5.4±1 ms) but longer under ketamine-xylazine (10.3±1.7 ms).
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Registered trials
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