ArticleBiomedical optics express2026
Translational photoacoustic and ultrasound imaging catheter for characterizing gastrointestinal inflammation and fibrosis: a study with a pig model
Article in Biomedical optics express, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- From lab design to clinical translation: photoacoustic endoscopy.Photoacoustics · 2026Review
- Introduction to the feature issue Photoacoustic Imaging and Sensing: Beyond Fundamentals to Translation.Biomedical optics express · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Our previous studies demonstrated that a prototype photoacoustic (PA) and ultrasound (US) imaging catheter can differentiate intestinal inflammation and fibrosis. However, its compatibility with clinical endoscopic procedures has not been validated. Here, we present a translational PA-US dual-modality imaging catheter with a reduced diameter to fit the biopsy channel of standard adult colonoscopes and therapeutic upper endoscopes (∼3.7 mm). The catheter integrates an angle-tipped optical fiber (600-µm core) for PA illumination and a miniaturized 48-element ultrasound array operating at a center frequency of ∼9 MHz for signal reception. These components are enclosed in a hydrostatic balloon (12 mm diameter, 15 mm length when fully inflated) to ensure acoustic coupling with the intestinal lumen. The system was upgraded from our previous setup by incorporating a more portable optical parametric oscillator (OPO) laser and a Verasonics imaging platform. The imaging catheter was positioned at the disease locations in a pig model of esophageal fibrosis induced by argon plasma coagulation (APC). Multi-wavelength PA imaging and US imaging were performed to resolve the tissue components. The results demonstrate the catheter's ability to assess inflammation and fibrosis in the gastrointestinal tract during a standard clinical endoscopy procedure.
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.