Evidence map›Paper›PMID 41532262›Full record

ArticleMovement disorders : official journal of the Movement Disorder Society2026

Beta-Band and Aperiodic Activity Across New and Chronic Subthalamic Nucleus Deep Brain Stimulation in Parkinson's Disease.

Arjun Balachandar, Alexandra Boogers, Sara Naghdlou, Andres M Lozano, Suneil K Kalia, Gerd Tinkhauser, Alfonso Fasano

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PubMed Full text at PMC Publisher
In one paragraph

Article in Movement disorders : official journal of the Movement Disorder Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Arjun BalachandarEdmond J. Safra Program in Parkinson's Disease and Morton and Gloria Shulman Movement Disorders Centre, Toronto Western Hospital, UHN, and Division of Neurology, University of Toronto, Toronto, Ontario, Canada.ORCID https://orcid.org/0000-0002-7658-4749
Alexandra BoogersEdmond J. Safra Program in Parkinson's Disease and Morton and Gloria Shulman Movement Disorders Centre, Toronto Western Hospital, UHN, and Division of Neurology, University of Toronto, Toronto, Ontario, Canada.ORCID https://orcid.org/0000-0002-5427-0781
Sara NaghdlouKrembil Brain Institute, Toronto, Ontario, Canada.
Andres M LozanoKrembil Brain Institute, Toronto, Ontario, Canada.
Suneil K KaliaKrembil Brain Institute, Toronto, Ontario, Canada.
Gerd TinkhauserDepartment of Neurology, Bern University Hospital and University of Bern, Bern, Switzerland.
Alfonso FasanoEdmond J. Safra Program in Parkinson's Disease and Morton and Gloria Shulman Movement Disorders Centre, Toronto Western Hospital, UHN, and Division of Neurology, University of Toronto, Toronto, Ontario, Canada.

Funding

Chair in Neuromodulation, University of Toronto and University Health Network, Toronto, ON, Canada
6 · The paper itself

Abstract

backgroundNeurophysiological biomarkers in Parkinson's disease (PD) are increasingly used for deep brain stimulation (DBS). Their long-term utility is not clear, especially when transitioning to sensing-guided DBS years post-surgery.

objectivesBeta-band power, bursting activity, and periodic and aperiodic components of local field potentials recorded from DBS electrodes in the subthalamic nucleus (STN) were compared between a group of newly and chronically (6.7 ± 4.0 years) implanted PD patients. Clinical severity was rated using the Movement Disorder Society-Unified Parkinson's Disease Rating Scale-Part III (MDS-UPDRS-III).

resultsBeta-band power and burst amplitude were significantly higher and aperiodic offset and exponent were significantly lower in the chronically implanted cohort. Periodic peak frequency and power were not significantly different. Clinical severity correlated with cumulative burst time and burst rate. A longitudinal subset showed no change in peak frequency or power.

conclusionsSTN beta-band-related biomarkers inform disease state of de novo and chronic PD-DBS cohorts, with signal properties relevant for sensing-guided DBS preserved over time. © 2026 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

Indexed as

Beta RhythmDeep Brain StimulationParkinson DiseaseSubthalamic NucleusAgedFemaleHumansLocal Field Potential MeasurementMaleMiddle AgedSeverity of Illness Indexbeta activitydeep brain stimulationlocal field potentialsParkinson's diseasesubthalamic nucleus

Identifiers

PMID41532262
PMCPMC13067303

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.