ArticleHypertension (Dallas, Tex. : 1979)2026
Sex-Specific Blood Pressure Thresholds in Middle-Aged Adults.
Katie Williams, Benjamin Grobman, Fredrick Larbi Kwapong, Hannah Col, Ruth-Alma N Turkson-Ocran, Long H Ngo, Mingyu Zhang, Natalie R Daya, Elizabeth Selvin, Pamela L Lutsey and 4 more
Abstract read
In one paragraphArticle in Hypertension (Dallas, Tex. : 1979), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
14 authors.
Katie Williams *Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA (K.W., B.G., F.L.K., H.C., R.-A.N.T.-O., L.H.N., M.Z., S.P.J.).
Benjamin Grobman *Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA (K.W., B.G., F.L.K., H.C., R.-A.N.T.-O., L.H.N., M.Z., S.P.J.).ORCID 0000-0002-4416-6243 Fredrick Larbi KwapongDepartment of Medicine, Beth Israel Deaconess Medical Center, Boston, MA (K.W., B.G., F.L.K., H.C., R.-A.N.T.-O., L.H.N., M.Z., S.P.J.).ORCID 0000-0002-5585-632X Hannah ColDepartment of Medicine, Beth Israel Deaconess Medical Center, Boston, MA (K.W., B.G., F.L.K., H.C., R.-A.N.T.-O., L.H.N., M.Z., S.P.J.).
Ruth-Alma N Turkson-OcranDepartment of Medicine, Beth Israel Deaconess Medical Center, Boston, MA (K.W., B.G., F.L.K., H.C., R.-A.N.T.-O., L.H.N., M.Z., S.P.J.).ORCID 0000-0001-9932-052X Long H NgoDepartment of Medicine, Beth Israel Deaconess Medical Center, Boston, MA (K.W., B.G., F.L.K., H.C., R.-A.N.T.-O., L.H.N., M.Z., S.P.J.).
Mingyu ZhangDepartment of Medicine, Beth Israel Deaconess Medical Center, Boston, MA (K.W., B.G., F.L.K., H.C., R.-A.N.T.-O., L.H.N., M.Z., S.P.J.).ORCID 0000-0003-3628-0983 Natalie R DayaHebrew SeniorLife Marcus Center, Department of Epidemiology, Johns Hopkins University, Baltimore, MD (N.R.D., E.S.).ORCID 0000-0002-2257-0480 Elizabeth SelvinHebrew SeniorLife Marcus Center, Department of Epidemiology, Johns Hopkins University, Baltimore, MD (N.R.D., E.S.).ORCID 0000-0001-6923-7151 Pamela L LutseyDivision of Epidemiology and Community Health, University of Minnesota, Minneapolis (P.L.L.).ORCID 0000-0002-1572-1340 B Gwen WindhamUniversity of Mississippi Medical Center, The MIND Center (B.G.W.).
Stephen P JuraschekDepartment of Medicine, Beth Israel Deaconess Medical Center, Boston, MA (K.W., B.G., F.L.K., H.C., R.-A.N.T.-O., L.H.N., M.Z., S.P.J.).ORCID 0000-0003-4168-2696 Funding
CARDIOVASCULAR EPIDEMIOLOGY INSTITUTIONAL TRAININGT32HL007024 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Elizabeth Selvin · 1985 to 2026
$17.5MTHE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - COORDINATING CENTER - TASK AREA B.2 AND B.375N92022D00001 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COUPER, DAVID · 2022 to 2025
$13.7MTHE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - FIELD CENTER - TASK ORDER 01, TASK AREA A75N92022D00003 · NHLBI · UNIVERSITY OF MINNESOTA · PI LUTSEY, PAMELA L. · 2022 to 2025
$5.1MTHE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - FIELD CENTER - TASK ORDER 01, TASK AREA A75N92022D00005 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI WAGENKNECHT, LYNNE E · 2022 to 2025
$5.0MTHE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - FIELD CENTER - TASK ORDER 01, TASK AREA A75N92022D00004 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI WINDHAM, BEVERLY GWEN · 2022 to 2025
$4.8MTHE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - FIELD CENTER - TASK ORDER 01, TASK AREA A75N92022D00002 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI CORESH, JOSEF · 2022 to 2025
$4.7MPrognostic Implications of Home-Based Blood Pressure Monitoring in Older AdultsR01HL158622 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI JURASCHEK, STEPHEN P · 2021 to 2025
$4.5MClinical Implications of Blood Pressure Patterns Among Older AdultsR01HL153191 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI JURASCHEK, STEPHEN P · 2021 to 2023
$2.3MClinical Implications of Blood Pressure Patterns Among Older AdultsR56HL153191 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI JURASCHEK, STEPHEN P · 2020 to 2020
$904kMentoring and Research in Patient-Oriented Cardiovascular PharmacoepidemiologyK24HL159246 · NHLBI · UNIVERSITY OF MINNESOTA · PI PAMELA L. Lutsey · 2021 to 2026
$644kResearch and Mentoring in the Clinical Epidemiology of Cardiovascular Disease and Type 2 DiabetesK24HL152440 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI SELVIN, ELIZABETH · 2020 to 2024
$612kNHLBI NIH HHS 75N92022D00001NHLBI NIH HHS 75N92022D00002NHLBI NIH HHS 75N92022D00003NHLBI NIH HHS 75N92022D00004NHLBI NIH HHS 75N92022D00005NHLBI NIH HHS K24 HL152440NHLBI NIH HHS K24 HL159246NHLBI NIH HHS R01 HL153191NHLBI NIH HHS R01 HL158622NHLBI NIH HHS R56 HL153191NHLBI NIH HHS T32 HL007024
6 · The paper itselfAbstract
backgroundHigher relative risk for cardiovascular disease (CVD) events at lower blood pressure (BP) thresholds in female versus male adults suggest that hypertension thresholds should be sex-specific.
methodsWe used the ARIC study (Atherosclerosis Risk in Communities) visit 1 (1987-1989) to compare the BP distribution, estimated risk (via the 10-year Predicting Risk of Cardiovascular Disease Events score), absolute risk, and relative risk of CVD according to BP thresholds, stratified by sex and hypertension treatment status, in participants without prior CVD.
resultsOf 13 418 participants (56% women, mean age [54±5.7 years]), 25% were treated for hypertension. Males had higher average 10-year CVD risk scores regardless of treatment. The distribution of BP and prevalence of CVD risk factors was similar for male and female adults. Incidence rates (per 10 000 person-years) comparing a systolic BP threshold of ≥140 versus <140 mm Hg for coronary heart disease were 30.9 and 12.0 among untreated male and female adults (
conclusionsIn this middle-aged population, there were no consistent differences in BP distribution, risk factor burden, absolute risk, or relative risk of CVD between male and female adults. These findings do not support a sex-specific threshold for hypertension.
Indexed as
Blood PressureCardiovascular DiseasesHypertensionAntihypertensive AgentsBlood Pressure DeterminationFemaleHeart Disease Risk FactorsHumansIncidenceMaleMiddle AgedPrevalenceRisk AssessmentRisk FactorsSex FactorsUnited StatesAntihypertensive Agentsadultblood pressurecardiologyhypertensionprevalence
Identifiers
PMID41532301
PMCPMC13261848
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