ArticleTranslational vision science & technology2026
A Simulation Procedure for Stereological Correction of Early AMD Lesion Sizes Observed in Single OCT-B-Scans.
Article in Translational vision science & technology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Review of emerging imaging findings to reveal a broader spectrum of lesions in AMD.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Review
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Early lesions caused by age-related macular degeneration (AMD) are imaged by optical coherence tomography (OCT) in unprecedented detail. Most probably, however, the sampling plane of an OCT scan meets a given lesion noncentrally, and the observed sizes of its diameter, cross-sectional area, and volume must be stereologically corrected. Methods: Stereological corrections are obtained by a simulation procedure, which is applied to the leading scans in a consecutive sample of 100 early AMD participants. Results: Mean corrections for lesion diameter, cross-sectional area and volume amount to +9.1%, +32.0%, and +46.6%, respectively. After correction, AMD stage classifications with respect to the 125-µm diameter cutpoint had to be changed for seven participants. Conclusions: Simulation results confirm that for lesions pictured and measured in OCT scans - regardless of the accuracy of OCT imaging - stereological correction of observed sizes is compelling and unavoidable. Translational Relevance: Categorial AMD classifications based on observed OCT data must be reexaminated after stereological correction.
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