Evidence map›Paper›PMID 41532832›Full record

ArticleChemistry & biodiversity2026

Chemical Composition and Biological Activities of Bubonium graveolens (Forssk) Maire Essential Oil: In Silico Evaluation of Its Major Compounds.

Roumaissa Halima Amamra, Radia Bouasla, Raoudha Ben Ameur, Karima Mellouk, Khadidja Otmane Rachedi, Lina Manel Djendi, Ouafa Meziani, Chahrazed Benzaid, Loubna Ferchichi, Chaima Zerrad and 4 more

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Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Roumaissa Halima AmamraLaboratory of Synthesis and Organic Biocatalysis, Department of Chemistry, Faculty of Sciences, Badji-Mokhtar Annaba University, Box 12, 23000 Annaba, Algeria.
Radia BouaslaLaboratory of Applied Organic Chemistry Sciences Faculty, Chemistry Department, Synthesis of Biomolecules and Molecular Modelling Group, Badji-Mokhtar Annaba University, Annaba, Algeria.
Raoudha Ben AmeurNatural Substances Team (LR17ES08), Faculty of Sciences of Sfax, Laboratory of Organic Chemistry, University of Sfax, Sfax, Tunisia.
Karima MelloukLaboratory of Synthesis and Organic Biocatalysis, Department of Chemistry, Faculty of Sciences, Badji-Mokhtar Annaba University, Box 12, 23000 Annaba, Algeria.
Khadidja Otmane RachediLaboratory of Applied Organic Chemistry Sciences Faculty, Chemistry Department, Synthesis of Biomolecules and Molecular Modelling Group, Badji-Mokhtar Annaba University, Annaba, Algeria.
Lina Manel DjendiLaboratory of Microbiology and Molecular Biology, Badji-Mokhtar Annaba University, Annaba, Algeria.
Ouafa MezianiLaboratory of Applied Organic Chemistry Sciences Faculty, Chemistry Department, Synthesis of Biomolecules and Molecular Modelling Group, Badji-Mokhtar Annaba University, Annaba, Algeria.
Chahrazed BenzaidLaboratory of Microbiology and Molecular Biology, Badji-Mokhtar Annaba University, Annaba, Algeria.
Loubna FerchichiLaboratory of Synthesis and Organic Biocatalysis, Department of Chemistry, Faculty of Sciences, Badji-Mokhtar Annaba University, Box 12, 23000 Annaba, Algeria.
Chaima ZerradLaboratory of Synthesis and Organic Biocatalysis, Department of Chemistry, Faculty of Sciences, Badji-Mokhtar Annaba University, Box 12, 23000 Annaba, Algeria.
Aicha RiziLaboratory of Applied Organic Chemistry Sciences Faculty, Chemistry Department, Synthesis of Biomolecules and Molecular Modelling Group, Badji-Mokhtar Annaba University, Annaba, Algeria.
Abdelkrim CheritiPhytochemistry and Organic Synthesis Laboratory, Bechar, Algeria.
Noureddine AlloucheNatural Substances Team (LR17ES08), Faculty of Sciences of Sfax, Laboratory of Organic Chemistry, University of Sfax, Sfax, Tunisia.
Malika BerredjemLaboratory of Applied Organic Chemistry Sciences Faculty, Chemistry Department, Synthesis of Biomolecules and Molecular Modelling Group, Badji-Mokhtar Annaba University, Annaba, Algeria.ORCID https://orcid.org/0000-0002-4312-8771

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While Bubonium graveolens (Forssk) Maire, locally known as "tafss," is renowned in traditional medicine for its diverse therapeutic properties, a comprehensive analysis linking its phytochemical profile to mechanistic bioactivity is lacking. In this study, the in vitro antimicrobial, anti-inflammatory, and antioxidant activities of its essential oil (EO) were evaluated using the disc diffusion, broth microdilution methods, and solid double dilution, the bovine serum albumin denaturation assay, and the 1,1-diphenyl-2-picrylhydrazyl radical scavenging test. The characterization of its phytochemical composition by gas chromatography coupled with mass spectrometry allowed for the identification of the main bioactive compounds: 3-methyl-3-cyclohexen-1-one (3.77%), dihydrocarvyl acetate (16.05%), cadinene (12.68%), butylated hydroxytoluene (4.24%), chrysanthenylacetate (2.57%), and β-panasinsene (2.42%). EO exhibited potent antimicrobial activity, particularly against Acinetobacter baumannii (DZI: 16 mm; minimum inhibitory concentration: 500 µg/mL), and reduced biofilm formation by up to 53%, whereas EO demonstrated superior antioxidant (IC

Indexed as

Anti-Bacterial AgentsAntioxidantsBoraginaceaeOils, VolatileAnimalsBiphenyl CompoundsMicrobial Sensitivity TestsMolecular Docking SimulationMolecular StructurePicratesStructure-Activity RelationshipAnti-Bacterial AgentsAntioxidantsBiphenyl CompoundsOils, VolatilePicratesADME/Toxicitybiological activitiesBubonium graveolensDFT studymolecular docking

Identifiers

PMID41532832
PMCPMC13420217

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.