Evidence map›Paper›PMID 41532854›Full record

ArticleChemistry & biodiversity2026

Exploring the Phytochemical Profile and Biological Activities, Supported by Molecular Docking and Dynamics Simulation Studies of Lysimachia tyrrhenia U.Manns & Anderb.

Lamia Djeblia, Naima Boutaghane, Samia Bendamene, Baiche Kenza, Laurence Voutquenne-Nazabadioko, Houssem Boulebd, Abedelghani May, Suresh Kumar, Kalavathi Murugan Kumar, Mustafa Abdullah Yilmaz and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Lamia DjebliaDépartement de Chimie, Laboratoire d'Obtention Des Substances Thérapeutiques (LOST), Campus Chaabet-Ersas, Université Des Frères Mentouri-Constantine 1, Constantine, Algeria.
Naima BoutaghaneDépartement de Chimie, Laboratoire d'Obtention Des Substances Thérapeutiques (LOST), Campus Chaabet-Ersas, Université Des Frères Mentouri-Constantine 1, Constantine, Algeria.
Samia BendameneDépartement de Chimie, Laboratoire d'Obtention Des Substances Thérapeutiques (LOST), Campus Chaabet-Ersas, Université Des Frères Mentouri-Constantine 1, Constantine, Algeria.
Baiche KenzaDépartement de Chimie, Laboratoire d'Obtention Des Substances Thérapeutiques (LOST), Campus Chaabet-Ersas, Université Des Frères Mentouri-Constantine 1, Constantine, Algeria.
Laurence Voutquenne-NazabadiokoCNRS, ICMR UMR 7312, Université De Reims Champagne Ardenne, Reims, France.ORCID https://orcid.org/0000-0001-7038-241X
Houssem BoulebdLaboratory of Synthesis of Molecules with Biological Interest, Department of Chemistry, Faculty of Exact Sciences, University Frères Mentouri Constantine 1, Constantine, Algeria.
Abedelghani MayDepartment of Chemistry, University Mentouri-Constantine 1, Constantine, Algeria.
Suresh KumarFaculty of Health and Life Sciences, Management and Science University, Shah Alam, Malaysia.
Kalavathi Murugan KumarDepartment of Bioinformatics, School of Life Science, Pondicherry University, (A Central University, Govt of India) Chinna Kalapet, Puducherry, India.
Mustafa Abdullah YilmazDepartment of Analytical Chemistry, Faculty of Pharmacy, Dicle University Science and Technology Research and Application Center (DUBTAM), Diyarbakır, Turkey.
Zahia KaboucheDépartement de Chimie, Laboratoire d'Obtention Des Substances Thérapeutiques (LOST), Campus Chaabet-Ersas, Université Des Frères Mentouri-Constantine 1, Constantine, Algeria.
Leila HambabaLaboratoire de Biotechnologie des Molécules Bioactives Et Physiopathologie Cellulaire Mustapha Ben Boulaid, Département de Microbiologie et Biochimie, Université Batna 2, Batna, Algeria.

Funding

Biotechnology Research Center (CRBt) (Constantine-Algeria)Conseil General de la Marne, Ministry of Higher Education and Research (MESR) in FranceConseil Regional Champagne ArdenneDGRSDT of the Ministry of Higher Education and Scientific Research of Algeria for PRFU Project B00L01UN250120220003PlANET CPER Project
6 · The paper itself

Abstract

The current research was conducted to explore for the first time the phytochemical composition, of the methanolic extract and the fractions of Lysimachia tyrrhenia U.Manns & Anderb. using a developed LC-ESI-MS/MS method. In addition, antioxidant, cholinesterase inhibitory, and photoprotective activities were evaluated to highlight the potential therapeutic relevance of this species. In vitro trials were undertaken to investigate the antioxidant activity of the L. tyrrhenia sampls based on 2-diphenyl-1-picrylhydrazyl (DPPH

Indexed as

AntioxidantsCholinesterase InhibitorsLysimachiaMolecular Docking SimulationMolecular Dynamics SimulationPhytochemicalsPlant ExtractsAcetylcholinesteraseBiphenyl CompoundsButyrylcholinesterasePicratesTandem Mass SpectrometryAcetylcholinesteraseAntioxidantsBiphenyl CompoundsButyrylcholinesteraseCholinesterase InhibitorsPhytochemicalsPicratesPlant Extractsanticholinesterase activityantioxidant activitydynamics simulationLC–ESI–MS/MS analysisLysimachia tyrrheniamolecular dockingsun protective activity

Identifiers

PMID41532854
PMCPMC13420219

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.