Evidence map›Paper›PMID 41533236›Full record

ArticleNeurochemical research2026

Probiotic Supplementation Modulates FGFR2 and TLR4 Signaling and Attenuates Chronic Neuroinflammation in an Experimental Stroke Model.

Reza Bayat, Zahra Rezvani, Shokouh Rahmatipour, Abolfazl Azami Tameh, Zeinab Vahidinia

Abstract read
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In one paragraph

Article in Neurochemical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Reza BayatDepartment of Cell and Molecular Biology, Faculty of Chemistry, University of Kashan, Kashan, Iran.
Zahra RezvaniDepartment of Cell and Molecular Biology, Faculty of Chemistry, University of Kashan, Kashan, Iran. rezvani@kashanu.ac.ir.
Shokouh RahmatipourDepartment of Cell and Molecular Biology, Faculty of Chemistry, University of Kashan, Kashan, Iran.
Abolfazl Azami TamehAnatomical Sciences Research Center, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran.
Zeinab VahidiniaAnatomical Sciences Research Center, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran.

Funding

Kashan University of Medical Sciences 402189/402190
6 · The paper itself

Abstract

Stroke is a major cause of mortality and morbidity. It is known to induce gut dysbiosis, which can exacerbate brain injury by increasing systemic inflammation and disrupting the gut-brain axis. This study investigated the effects of probiotics on immunomodulation and brain regeneration in a post-stroke animal model, with a particular focus on gut-brain axis. In this study, Male Wistar rats were divided into three groups: Sham, Ischemia and Ischemia + Probiotic. Focal cerebral ischemia was induced by one-hour middle cerebral artery occlusion (MCAO). The probiotic group received 10

Indexed as

Neuroinflammatory DiseasesProbioticsStrokeToll-Like Receptor 4AnimalsDisease Models, AnimalInfarction, Middle Cerebral ArteryMaleMolecular Docking SimulationOxidative StressRatsRats, WistarSignal TransductionTlr4 protein, ratToll-Like Receptor 4FGFR2Gut-brain axisIschemic strokeMMP-9ProbioticsTLR4

Identifiers

PMID41533236

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.