Evidence map›Paper›PMID 41533438›Full record

ArticleThe Journal of general virology2026

The cellular activating protein-1 cFos regulates influenza A virus replication.

Antoine Gerodez, François E Dufrasne, Olivier Denis, Mieke Steensels, Bénédicte Lambrecht, Lionel Tafforeau, Caroline Demeret, Cyril Barbezange

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of general virology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Antoine GerodezNational Influenza Center, Sciensano, 1180 Brussels, Belgium.
François E DufrasneNational Influenza Center, Sciensano, 1180 Brussels, Belgium.
Olivier DenisImmune Response Service, Sciensano, 1180 Brussels, Belgium.
Mieke SteenselsAvian Virology and Immunology Service, Sciensano, 1180 Brussels, Belgium.
Bénédicte LambrechtAvian Virology and Immunology Service, Sciensano, 1180 Brussels, Belgium.
Lionel TafforeauCell Biology laboratory, Research Institute for Health Sciences and Technologies, University of Mons, 7000 Mons, Belgium.
Caroline DemeretInteractomics, RNA and Immunity laboratory, Institut Pasteur, 75015 Paris, France.
Cyril BarbezangeNational Influenza Center, Sciensano, 1180 Brussels, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Previous research has demonstrated that influenza A virus (IAV) infection activates activating protein-1 (AP-1) transcription factors as part of the antiviral response. In this study, we identified cFos as the most upregulated AP-1 transcription factor during IAV infection in A549 human lung cells. Surprisingly, the knockdown of cFos resulted in impaired IAV replication. Fluorescence microscopy and functional analyses indicated that cFos is implicated in IAV infection through its nuclear function, rather than its cytoplasmic role as an activator of lipid synthesis. The investigation into the role of cFos in IAV infection revealed increased apoptosis and elevated interferon-

Indexed as

Influenza A virusInfluenza, HumanTranscription Factor AP-1Virus ReplicationA549 CellsApoptosisGene Knockdown TechniquesHost-Pathogen InteractionsHumansImmunity, InnateInterferon-betaInterferon-betaTranscription Factor AP-1AP-1apoptosiscFosinfluenza A virusinterferontranscription factor

Identifiers

PMID41533438
PMCPMC12804346

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.