Evidence map›Paper›PMID 41533444›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Negative feedback regulation of alcohol ingestion through the FGF21-PVH oxytocin-VTA dopamine system.

Sho Matsui, Yuma Takahashi, Shuhei Morioka, Takaaki Ozawa, Sachiho Kanayama, Hiroki Iwama, Lan Geng, Kazuhiro Umemoto, Yasuo Oguri, Satoshi Tsuzuki and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Sho MatsuiLaboratory of Nutrition Chemistry, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan.
Yuma Takahashi *Laboratory of Nutrition Chemistry, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan.
Shuhei Morioka *Laboratory of Nutrition Chemistry, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan.
Takaaki OzawaLaboratory for Advanced Brain Functions, Institute for Protein Research, Osaka University, Suita, Osaka 565-0871, Japan.
Sachiho KanayamaLaboratory of Nutrition Chemistry, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan.
Hiroki IwamaLaboratory of Nutrition Chemistry, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan.
Lan GengState Key Laboratory of Membrane Biology, School of Life Sciences, Peking University, Beijing 100871, China.
Kazuhiro UmemotoLaboratory for Advanced Brain Functions, Institute for Protein Research, Osaka University, Suita, Osaka 565-0871, Japan.
Yasuo OguriLaboratory of Nutrition Chemistry, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan.
Satoshi TsuzukiLaboratory of Nutrition Chemistry, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan.
Yulong LiState Key Laboratory of Membrane Biology, School of Life Sciences, Peking University, Beijing 100871, China.
Takatoshi HikidaLaboratory for Advanced Brain Functions, Institute for Protein Research, Osaka University, Suita, Osaka 565-0871, Japan.
Tsutomu SasakiLaboratory of Nutrition Chemistry, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan.ORCID 0000-0001-8041-1915

Funding

Japan Food Chemical Research Foundation (JFCRF) n/aJapan Health Foundation n/aJapan Neurosurgical Society n/aKato Memorial Bioscience Foundation n/aKowa Life Science Foundation n/aKyoto Funding for Innovation in Health-related R&D Fields/Kyoto City Hall and Kyoto Lifetech Innovation Support Center (KLISC) n/aLotte Foundation n/aMEXT | Japan Society for the Promotion of Science (JSPS) 18K19726MEXT | Japan Society for the Promotion of Science (JSPS) 19K11738MEXT | Japan Society for the Promotion of Science (JSPS) 20K21756Suzuken Memorial Foundation (SMF) n/athe Collaborative Research Program of the Institute for Protein Research, Osaka University CR-24-03TOBE MAKI Scholarship Foundation n/aToyo Suisan Foundation (THE TOYO SUISAN FOUNDATION) n/aUrakami Foundation for Food and Food Culture Promotion (・) n/a
6 · The paper itself

Abstract

Alcohol has a notable negative impact on global health. Understanding its physiological regulation is crucial to addressing alcohol use. Here, we show that FGF21-oxytocin neurons in the paraventricular nucleus of the hypothalamus (PVH

Indexed as

Alcohol DrinkingDopaminergic NeuronsFibroblast Growth FactorsOxytocinParaventricular Hypothalamic NucleusVentral Tegmental AreaAlcoholismAnimalsDopamineEthanolFeedback, PhysiologicalMaleMiceMice, Inbred C57BLSignal TransductionDopamineEthanolfibroblast growth factor 21Fibroblast Growth FactorsOxytocinalcohol dependencedopamineFGF21oxytocinrare sugar

Identifiers

PMID41533444
PMCPMC12818416

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.