Evidence map›Paper›PMID 41533775›Full record

ArticleScience translational medicine2026

Endothelial cell-released CD93 contributes to podocyte injury in idiopathic nephrotic syndrome.

Colin Bauer, Federica Piani, Jonathan Troost, Stefano Da Sacco, Guadalupe Rojas-Sanchez, Pavel Davizon-Castillo, Laura Perin, Ilse Daehn, Md Imtiazul Islam, Audrey Fetsko and 45 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science translational medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

55 authors.

Colin BauerDepartment of Pediatrics, Section of Pediatric Nephrology, Children's Hospital Colorado, Aurora, CO 80045, USA.ORCID 0009-0001-3745-9603
Federica PianiDepartment of Pediatrics, Section of Pediatric Nephrology, Children's Hospital Colorado, Aurora, CO 80045, USA.ORCID 0000-0003-3338-1172
Jonathan TroostMichigan Institute for Clinical and Health Research, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-1183-8330
Stefano Da SaccoGOFARR Laboratory for Organ Regenerative Research and Cell Therapeutics in Urology, Saban Research Institute, Division of Urology, Children's Hospital Los Angeles (CHLA), Los Angeles, CA 90027, USA.ORCID 0000-0001-9654-6822
Guadalupe Rojas-SanchezBloodWorks Northwest, Seattle, WA 98104, USA.ORCID 0000-0001-6600-6411
Pavel Davizon-CastilloBloodWorks Northwest, Seattle, WA 98104, USA.ORCID 0000-0002-3677-4476
Laura PerinGOFARR Laboratory for Organ Regenerative Research and Cell Therapeutics in Urology, Saban Research Institute, Division of Urology, Children's Hospital Los Angeles (CHLA), Los Angeles, CA 90027, USA.ORCID 0000-0002-6955-6416
Ilse DaehnDepartment of Medicine, Division of Nephrology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0001-9915-5376
Md Imtiazul IslamKidney and Urinary Tract Center, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH 43205, USA.ORCID 0000-0002-0020-6733
Audrey FetskoKidney and Urinary Tract Center, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH 43205, USA.ORCID 0000-0003-2256-5793
Claudia Carrera-MuñozDepartment of Pediatrics, Section of Pediatric Nephrology, Children's Hospital Colorado, Aurora, CO 80045, USA.ORCID 0009-0007-5612-9574
Brad RovinDivision of Nephrology, Ohio State University, Columbus, OH 43210, USA.ORCID 0000-0001-5639-0210
Xiaolan L ZhangDivision of Nephrology, Ohio State University, Columbus, OH 43210, USA.
Mindy BanksRocky Mountain Pediatric Kidney Center, Rocky Mountain Hospital for Children, Denver, CO 80205, USA.ORCID 0009-0005-2481-293X
Carmen de Lucas-CollantesDepartment of Pediatric Nephrology, Hospital Niño Jesus, Madrid 28009, Spain.ORCID 0000-0002-4882-0425
Flor A Ordóñez-ÁlvarezDepartment of Pediatric Nephrology, Hospital Universitario Central de Asturias, Oviedo 33011, Spain.ORCID 0000-0002-5003-9195
Cristina Aparicio-LópezDepartment of Pediatric Nephrology, Hospital Niño Jesus, Madrid 28009, Spain.ORCID 0009-0006-5188-2455
Miguel A LanaspaDivision of Endocrinology, Metabolism and Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0002-1163-1831
Ana Andres-HernandoDivision of Endocrinology, Metabolism and Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Alfons SegarraDepartment of Nephrology, Hospital Universitario Arnau de Vilanova, Lleida 25198, Spain.ORCID 0000-0002-4349-2856
Cristina MartinezRenal Physiopathology Group, Vall d'Hebron Research Institute (VHIR), Barcelona 08035, Spain.ORCID 0000-0002-9368-1356
Petter BjornstadDivision of Endocrinology, Metabolism, and Nutrition, University of Washington School of Medicine, Seattle, WA 98109, USA.
M Scott LuciaDepartment of Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Franz SchaeferPediatric Nephrology Division, Heidelberg University Hospital, Heidelberg 69120, Germany.ORCID 0000-0001-7564-9937
Alev YilmazIstanbul Faculty of Medicine, Istanbul University, Istanbul 34093, Türkiye.ORCID 0000-0003-1743-1491
Aleksandra ZurowskaDepartment of Pediatric and Adolescent Nephrology, Medical University of Gdansk, Gdansk 80-210, Poland.ORCID 0000-0002-3354-5344
Xin WangKidney and Urinary Tract Center, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH 43205, USA.ORCID 0000-0003-1456-335X
Phillip J McCownDivision of Nephrology, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-8012-1931
Sean EddyDivision of Nephrology, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0001-8578-3443
John HartmanDivision of Nephrology, University of Michigan, Ann Arbor, MI 48109, USA.
Laura MarianiDivision of Nephrology, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-6055-764X
Matthias KretzlerDivision of Nephrology, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0003-4064-0582
Yuwen ZhuDepartment of Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0003-1434-6590
Antonia H M BoutsDepartment of Pediatric Nephrology, Emma Children's Hospital, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam 1105, Netherlands.ORCID 0000-0002-4121-6698
Elena N LevtchenkoDepartment of Pediatric Nephrology, Emma Children's Hospital, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam 1105, Netherlands.ORCID 0000-0002-8352-7312
Julie A DoughertyCenter for Clinical and Translational Research, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH 43205, USA.ORCID 0000-0001-5778-1512
William E SmoyerCenter for Clinical and Translational Research, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH 43205, USA.
Bryce A KerlinCenter for Clinical and Translational Research, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH 43205, USA.ORCID 0000-0002-1756-8271
Mahmoud KallashDivision of Pediatric Nephrology, Nationwide Children's Hospital, Columbus, OH 43205, USA.
Danielle E SorannoDepartment of Pediatrics, Section of Nephrology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0001-7019-809X
José E Cabrera-SevillaDepartment of Pediatrics, Division of Pediatric Nephrology, Hospital Universitario Santa Lucia, Cartagena 30202, Spain.ORCID 0000-0002-6269-9692
Juan David Gonzalez-RodriguezDepartment of Pediatrics, Division of Pediatric Nephrology, Hospital Universitario Santa Lucia, Cartagena 30202, Spain.ORCID 0000-0002-8863-2007
Bradford J SiegeleDepartment of Pathology and Laboratory Medicine, Children's Hospital Colorado, Aurora, CO 80045, USA.
Shoji TsujiDepartment of Pediatrics, Kansai Medical University, Osaka 573-1191, Japan.ORCID 0000-0003-3607-8355
Kazunari KanekoDepartment of Pediatrics, Kansai Medical University, Osaka 573-1191, Japan.ORCID 0000-0002-8215-0832
Christine B SethnaDivision of Pediatric Nephrology, Cohen Children's Medical Center, New York, NY 11042, USA.
Tarak SrivastavaPediatric Nephrology, Children's Mercy Hospital, Kansas City, MO 64108, USA.ORCID 0000-0002-8654-0627
Markus BitzerDivision of Nephrology, University of Michigan, Ann Arbor, MI 48109, USA.
Christopher L O'ConnorDivision of Nephrology, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0009-0002-1888-728X
Anna DimbergDepartment of Immunology, Genetics and Pathology, Science for Life Laboratory, Rudbeck Laboratory, Uppsala University, Uppsala 75185, Sweden.ORCID 0000-0003-4422-9125
Serena ZhaoDepartment of Medicine, Division of Nephrology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0009-0009-6985-821X
Liping YuDepartment of Medicine, Division of Nephrology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Joshua M ThurmanDepartment of Medicine, Division of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0001-9062-3559
Richard J JohnsonDepartment of Medicine, Division of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0003-3312-8193
Gabriel Cara-FuentesDepartment of Pediatrics, Section of Pediatric Nephrology, Children's Hospital Colorado, Aurora, CO 80045, USA.ORCID 0000-0002-4164-3251

Funding

Glomerular Cell-Cell Crosstalk and InjuryR01DK097253 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI DAEHN, ILSE SOFIA · 2013 to 2025
$7.3M
Genetic risk and molecular characterization of Diabetic Kidney DiseaseR01DK139395 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Ilse Sofia Daehn · 2024 to 2026
$1.0M
Inflammation-associated Autophagy DysfunctionR00HL177831 · NHLBI · SEATTLE CHILDREN'S HOSPITAL · PI Pavel Davizon-Castillo · 2025 to 2026
$934k
Inflammation-mediated platelet hyperreactivity and thrombosisK99HL156058 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI DAVIZON-CASTILLO, PAVEL · 2021 to 2024
$852k
Evidence For Endothelial Involvement in Idiopathic Nephrotic Syndrome: A Role for CD93K08DK134761 · NIDDK · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI Gabriel Miguel Cara Fuentes · 2024 to 2026
$461k
NHLBI NIH HHS K99 HL156058NHLBI NIH HHS R00 HL177831NIDDK NIH HHS K08 DK134761NIDDK NIH HHS R01 DK097253NIDDK NIH HHS R01 DK139395
6 · The paper itself

Abstract

Idiopathic nephrotic syndrome (INS) is a podocyte disease triggered by immune-derived factors. Endothelial activation occurs in this context, but whether the activated endothelium contributes to podocyte injury is unknown. We tested the hypothesis that CD93, a protein primarily expressed in the endothelium, is a contributory factor of podocyte injury. We studied 460 patients with INS and 150 with other podocytopathies. CD93 was analyzed in kidney tissue, urine, and serum samples. We tested the efficacy of CD93 blockade in vitro and in vivo and investigated the relationship between soluble CD93 and clinical outcomes in human INS. CD93 was highly expressed by glomerular endothelial cells (GEnCs) in human INS, and INS sera stimulated cultured human GEnCs to release CD93. Mechanistically, soluble CD93 mediated podocyte activation via β1 integrin/FAK signaling in cultured human podocytes. CD93 blockade mitigated the activation of cultured human podocytes and albumin permeability in human GEnC-podocyte cocultures as well as albuminuria, glomerulosclerosis, and podocyte loss in two models of nephrotic syndrome: podocyte-specific transforming growth factor-β1 signaling (

Indexed as

Endothelial CellsMembrane GlycoproteinsNephrotic SyndromePodocytesAdultAnimalsDoxorubicinFemaleHumansIntegrin beta1Kidney GlomerulusMaleMiceMice, KnockoutMiddle AgedProteinuriacomplement 1q receptorDoxorubicinIntegrin beta1Membrane GlycoproteinsReceptors, ComplementTransforming Growth Factor beta1

Identifiers

PMID41533775
PMCPMC12989113

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.