Evidence map›Paper›PMID 41533786›Full record

ArticleScience advances2026

YAP/TAZ-VGLL3 governs adipocyte fate via epigenetic reprogramming of PPARγ and its target enhancers.

Taejun Seol, Ju-Gyeong Kang, Kwangmin Ryu, Woojae Kim, Daehee Hwang, Suhyeon Cho, Daeun Song, Bomin Ku, Yen T H Tran, Sun-Hye Jeong and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Taejun SeolNational Creative Research Center for Cell Plasticity, KAIST Stem Cell Center, Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea.ORCID 0000-0003-1738-9297
Ju-Gyeong KangNational Creative Research Center for Cell Plasticity, KAIST Stem Cell Center, Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea.ORCID 0000-0002-3397-232X
Kwangmin RyuDepartment of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea.ORCID 0000-0003-0570-1917
Woojae KimDepartment of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea.ORCID 0009-0004-3870-9047
Daehee HwangNational Creative Research Center for Cell Plasticity, KAIST Stem Cell Center, Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea.ORCID 0000-0003-1038-9200
Suhyeon ChoNational Creative Research Center for Cell Plasticity, KAIST Stem Cell Center, Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea.ORCID 0009-0001-9716-6386
Daeun SongNational Creative Research Center for Cell Plasticity, KAIST Stem Cell Center, Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea.
Bomin KuNational Creative Research Center for Cell Plasticity, KAIST Stem Cell Center, Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea.ORCID 0000-0003-3074-4804
Yen T H TranNational Creative Research Center for Cell Plasticity, KAIST Stem Cell Center, Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea.ORCID 0000-0003-1414-2328
Sun-Hye JeongNational Creative Research Center for Cell Plasticity, KAIST Stem Cell Center, Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea.ORCID 0000-0003-4632-4812
Won-Ki ChoDepartment of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea.ORCID 0000-0001-9336-0686
Dae-Sik LimNational Creative Research Center for Cell Plasticity, KAIST Stem Cell Center, Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea.ORCID 0000-0003-2356-7555

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adipocyte differentiation from mesenchymal stem cells is governed by tightly regulated transcriptional and epigenetic programs. The Hippo pathway effectors YAP and TAZ impede this process, yet the underlying molecular mechanisms remain unclear. Here, we demonstrate how YAP/TAZ regulate transcription of the adipocyte lineage specification factor PPARγ and its target genes at the chromatin level. TAZ represses PPARγ-bound target enhancers as evidenced by a markedly reduced histone H3 acetylated at lysine-27 occupancy, resulting in the transcriptional repression of adipogenic genes, including

Indexed as

Adaptor Proteins, Signal TransducingAdipocytesEnhancer Elements, GeneticEpigenesis, GeneticPhosphoproteinsPPAR gammaTranscription Factors3T3-L1 CellsAdipogenesisAnimalsCell Cycle ProteinsCell DifferentiationHumansMesenchymal Stem CellsMiceTrans-ActivatorsAdaptor Proteins, Signal TransducingCell Cycle ProteinsPhosphoproteinsPPAR gammaTrans-ActivatorsTranscription FactorsWwtr1 protein, mouseYap1 protein, mouseYAP-Signaling Proteins

Identifiers

PMID41533786
PMCPMC12802833

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.