Evidence map›Paper›PMID 41534526›Full record

ArticleCell metabolism2026

Cytoarchitectural multi-depot profiling reveals immune-metabolic crosstalk in human colon-associated adipose tissue.

Jutta Jalkanen, Jiawei Zhong, Pamela A Nono Nankam, Nayanika Bhalla, Merve Elmastas, Jiaxin Luo, Sophie Weinbrenner, Scott Frendo-Cumbo, Benedek Pesti, William Gourash and 15 more

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In one paragraph

Article in Cell metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Jutta JalkanenDepartment of Medicine (H7), Karolinska Institutet, C2-94, Karolinska University Hospital, Stockholm, Sweden.
Jiawei ZhongDepartment of Medicine (H7), Karolinska Institutet, C2-94, Karolinska University Hospital, Stockholm, Sweden.
Pamela A Nono NankamHelmholtz Institute for Metabolic, Obesity, and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig, University Hospital Leipzig, Leipzig, Germany.
Nayanika BhallaScience for Life Laboratory, Department of Gene Technology, KTH Royal Institute of Technology, Solna, Sweden.
Merve ElmastasDepartment of Medicine (H7), Karolinska Institutet, C2-94, Karolinska University Hospital, Stockholm, Sweden.
Jiaxin LuoDepartment of Medicine (H7), Karolinska Institutet, C2-94, Karolinska University Hospital, Stockholm, Sweden.
Sophie WeinbrennerDepartment of Medicine (H7), Karolinska Institutet, C2-94, Karolinska University Hospital, Stockholm, Sweden; Helmholtz Institute for Metabolic, Obesity, and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig, University Hospital Leipzig, Leipzig, Germany.
Scott Frendo-CumboDepartment of Medicine (H7), Karolinska Institutet, C2-94, Karolinska University Hospital, Stockholm, Sweden.
Benedek PestiScience for Life Laboratory, Department of Gene Technology, KTH Royal Institute of Technology, Solna, Sweden.
William GourashDepartment of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Anita CourcoulasDepartment of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Zinger Yang LoureiroDivision of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Arne DietrichClinic for Visceral, Transplantation, and Thorax and Vascular Surgery, University Hospital Leipzig, Leipzig, Germany.
Jesper BäckdahlDepartment of Medicine (H7), Karolinska Institutet, C2-94, Karolinska University Hospital, Stockholm, Sweden.
Anders ThorellDepartment of Clinical Sciences, Karolinska Institutet, Danderyd Hospital, Department of Surgery, Ersta Hospital, Stockholm, Sweden.
Marcus BuggertCenter for Infectious Medicine, Department of Medicine Huddinge (H7), Karolinska Institutet, Karolinska University Hospital Huddinge, Huddinge, Sweden.
Joanna KaluckaDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.
Margo P EmontDepartment of Medicine, Section of Endocrinology, Diabetes, and Metabolism, University of Chicago, Chicago, IL, USA.
Evan D RosenDivision of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
Matthias BlüherHelmholtz Institute for Metabolic, Obesity, and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig, University Hospital Leipzig, Leipzig, Germany; Medical Department III - Endocrinology, Nephrology and Rheumatology, University of Leipzig Medical Center, Leipzig, Germany.
Peter KovacsMedical Department III - Endocrinology, Nephrology and Rheumatology, University of Leipzig Medical Center, Leipzig, Germany.
Patrik L StåhlScience for Life Laboratory, Department of Gene Technology, KTH Royal Institute of Technology, Solna, Sweden.
Lucas MassierDepartment of Medicine (H7), Karolinska Institutet, C2-94, Karolinska University Hospital, Stockholm, Sweden; Helmholtz Institute for Metabolic, Obesity, and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig, University Hospital Leipzig, Leipzig, Germany. Electronic address: lucas.massier@helmholtz-munich.de.
Mikael RydénDepartment of Medicine (H7), Karolinska Institutet, C2-94, Karolinska University Hospital, Stockholm, Sweden; Steno Diabetes Center Copenhagen, Herlev, Denmark. Electronic address: mikael.ryden@ki.se.
Niklas MejhertDepartment of Medicine (H7), Karolinska Institutet, C2-94, Karolinska University Hospital, Stockholm, Sweden; Steno Diabetes Center Copenhagen, Herlev, Denmark. Electronic address: niklas.mejhert@ki.se.

Funding

Transgenic CoreP30DK046200 · NIDDK · TUFTS MEDICAL CENTER · PI GREENBERG, ANDREW S, PERISSI, VALENTINA · 1992 to 2021
$25.0M
Investigating Human Adipocyte HeterogeneityRC2DK116691 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Orr Ashenberg, Noel P Burtt · 2018 to 2026
$17.8M
NIDDK NIH HHS P30 DK046200NIDDK NIH HHS RC2 DK116691
6 · The paper itself

Abstract

While it is well established that the cellular composition of white adipose tissue (WAT) varies between depots, the functional relevance of this heterogeneity remains unclear. By combining spatial and single-nucleus RNA sequencing, we provide a comprehensive map of subcutaneous and visceral (omental, mesenteric, mesocolic, and epiploic) WAT in both men and women. Our analyses reveal shared features, such as the spatial organization of adipogenesis, alongside depot-specific characteristics, including distinct cell-type enrichments and unique cell-cell communication routes. Epiploic WAT stands out by harboring high proportions of serum amyloid A expressing fat cells (encoded by SAA1/SAA2) and several leukocyte populations. Through mechanistic studies, we demonstrate that adipocyte SAA1/SAA2 expression is induced by inflammatory signals, including lipopolysaccharide, and that SAA1 activates immune responses in adipose-resident myeloid cells. Collectively, our findings suggest that visceral WAT exhibits distinct cytoarchitectural properties, with those located near the colon adapting by developing specialized adipocytes and immune cell populations.

Indexed as

Adipose Tissue, WhiteColonAdipocytesAnimalsFemaleHumansMaleSerum Amyloid A ProteinSAA1 protein, humanSerum Amyloid A Proteinadipocyte subtypesadipose depotscell-cell communicationcellular heterogeneityinflammationinsulin resistancemicrobiomeobesitytranscriptomics

Identifiers

PMID41534526
PMCPMC12989110

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.