ArticleNPJ Parkinson's disease2026
Super-resolution ultrasound imaging indirectly reveals neurovascular uncoupling in substantia nigra of a Parkinson's disease model.
Article in NPJ Parkinson's disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Reduced microvascular coverage links a hypoxia-associated niche to microglial autophagic dysfunction in Parkinson's disease.Acta neuropathologica communications · 2026Article
- Article
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Authors and funding
8 authors.
Funding
Abstract
Neurovascular coupling contributes to the regulation of cognitive function in Parkinson's disease (PD). However, the correlation between structural and functional integrity of neurovascular unit in substantia nigra and cognitive impairment in PD remains poorly understood. Using super-resolution ultrasound imaging (SRUS), this study aimed to explore the interplay among dopaminergic neurons, microcirculation, and cognitive function in 6-hydroxydopamine-induced PD rat model. The model exhibited impaired motor and cognitive abilities, along with substantia nigra hyperechogenicity detected via transcranial sonography. SRUS revealed reduced microvascular density, complexity, and velocity, alongside increased vessel tortuosity in the substantia nigra. These changes were accompanied by elevated expression of MMP9, CD4, Iba 1, and GFAP, and decreased levels of TH, GLUT-1 and Laminin. Levodopa treatment prevented dopaminergic neurons degeneration, reduced substantia nigra hyperechogenicity, restored microvascular structure and function, as well as alleviated neuroinflammation, which may contribute to improved cognitive performance. These findings suggest that SRUS can effectively detect microvascular alterations in the substantia nigra in a 6-hydroxydopamine-induced PD rat model. Dysfunction neurovascular coupling, likely mediated by dopaminergic neuronal injury, may play a role in PD-related cognitive impairment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.