Evidence map›Paper›PMID 41535376›Full record

ArticleScientific reports2026

Single-cell and multi-omic characterization of ex vivo expanded ASTRLs from stable kidney transplant recipients reveals a regulatory T cell phenotype.

Sudipta Tripathi, Amélie M Julé, Zhu Zhuo, Brittany L Schreiber, Paloma L Martin-Moreno, Shannan Ho Sui, Ana Maria Waaga-Gasser, Anil Chandraker

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In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sudipta TripathiRenal Division, Department of Medicine, UMass Chan Medical School, Worcester, MA, USA. sudipta.tripathi@umassmed.edu.
Amélie M JuléDepartment of Biostatistics, Harvard Chan Bioinformatics Core, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Zhu ZhuoDepartment of Biostatistics, Harvard Chan Bioinformatics Core, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Brittany L SchreiberRenal Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Paloma L Martin-MorenoNephrology Department, Clinica Universidad de Navarra, Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain.
Shannan Ho SuiDepartment of Biostatistics, Harvard Chan Bioinformatics Core, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Ana Maria Waaga-GasserRenal Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Anil ChandrakerRenal Division, Department of Medicine, UMass Chan Medical School, Worcester, MA, USA. anil.chandraker4@umassmed.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Therapeutic application of ex vivo expanded regulatory T cells is a promising approach to prolong allograft survival. In this work we performed a detailed characterization of a preclinical heterogenous antigen specific T enriched regulatory cell line (ASTRL) expanded ex vivo from PBMC of stable kidney transplant recipients. We used three different approaches: scRNA-seq, flow cytometry and mass cytometry, to compare pre-expansion PBMC to post-expansion ASTRL. Results show the CD4

Indexed as

Kidney TransplantationT-Lymphocytes, RegulatoryCell LineFemaleFlow CytometryGene Expression ProfilingHumansPhenotypeSingle-Cell AnalysisTranscriptomeTransplant Recipients

Identifiers

PMID41535376
PMCPMC12847790

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.