ReviewCurrent obesity reports2026
Vitamin A Derivatives and Adipose Tissue Differentiation: Molecular Pathways Driving Browning and Anti-Obesity Effects.
Review in Current obesity reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Effects of Medium-Chain Versus Medium- and Long-Chain Triglycerides, Combined with Carotenoids, in a High-Fat Diet on Obese Mice.Foods (Basel, Switzerland) · 2026Article
- C/EBPα plays a critical role in adipocyte differentiation and obesity.Frontiers in molecular biosciences · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of the reviewThis review aims to evaluate the effects of retinoids and carotenoids (β-carotene, lycopene, lutein, and β-cryptoxanthin) on adipose tissue biology, particularly browning processes, in light of the current literature. In the current era of increasing global obesity prevalence, understanding the potential regulatory roles of these lipophilic micronutrients in energy homeostasis and adipose tissue plasticity may contribute to the development of new nutrition-based or pharmacological strategies. RECENT
findingsThe regulatory roles of vitamin A (VA) and carotenoids in adipose tissue metabolism have been intensively investigated in recent years. Current findings indicate that compounds such as retinoic acid, lycopene, β-cryptoxanthin, and zeaxanthin reduce adipogenesis and lipogenesis by suppressing the expression of peroxisome proliferator-activated receptor gamma (PPARγ), CCAAT/enhancer binding protein alpha (C/EBPα), and sterol regulatory element-binding protein 1c (SREBP1-c) while increasing energy expenditure and promoting the browning of white adipose tissue through the activation of 5′-adenosine monophosphate-activated protein kinase (AMPK) and the upregulation of thermogenic genes such as uncoupling protein 1 (UCP1), PR domain containing 16 (PRDM16), and PPARγ coactivator-1α (PGC-1α). These effects are associated with reduced adipocyte hypertrophy, increased mitochondrial activity, and decreased systemic inflammation. VA and carotenoids exert multifaceted effects on adipose tissue differentiation and energy metabolism, suggesting an alternative pathway against obesity. By reducing lipid storage, stimulating thermogenesis, and enhancing oxidative metabolism, these bioactive compounds help restore metabolic balance. Overall, evidence indicates that VA derivatives and carotenoids, through adipose tissue browning and improved metabolic efficiency, represent promising nutrition-based strategies to combat obesity.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.