Evidence map›Paper›PMID 41535559›Full record

ArticleMolecular psychiatry2026

Associations between mosaic loss and schizophrenia or bipolar disorder of young age.

Shunsuke Uchiyama, Takeo Saito, Xiaoxi Liu, Yuki Ishikawa, Keiko Hikino, Masashi Ikeda, Giulio Genovese, Nakao Iwata, Chikashi Terao

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shunsuke Uchiyama *Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.ORCID http://orcid.org/0009-0000-7519-9534
Takeo Saito *Department of Psychiatry, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Katsukake-cho, Toyoake, Aichi, 470-1191, Japan.ORCID http://orcid.org/0000-0003-3671-4585
Xiaoxi LiuLaboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Yuki IshikawaLaboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.ORCID http://orcid.org/0000-0002-6514-8239
Keiko HikinoLaboratory for Pharmacogenomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.ORCID http://orcid.org/0000-0002-4852-2401
Masashi IkedaDepartment of Psychiatry, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Katsukake-cho, Toyoake, Aichi, 470-1191, Japan.
Giulio GenoveseProgram in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-3066-5575
Nakao IwataDepartment of Psychiatry, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Katsukake-cho, Toyoake, Aichi, 470-1191, Japan. nakao@fujita-hu.ac.jp.ORCID http://orcid.org/0000-0003-3189-6076
Chikashi TeraoLaboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan. chikashi.terao@riken.jp.ORCID http://orcid.org/0000-0002-6452-4095

Funding

Japan Agency for Medical Research and Development (AMED) 21ek0109555, 21tm0424220, 21ck0106642, 23ek0410114, 23tm0424225Japan Agency for Medical Research and Development (AMED) JP21wm0425008Japan Agency for Medical Research and Development (AMED) JP21wm0425008, JP23tm0524001, JP21wm0525024, 21tm0424220, JP23dk0307123MEXT | Japan Society for the Promotion of Science (JSPS) JP20H00462MEXT | Japan Society for the Promotion of Science (JSPS) JP21H02854, 24K02381MEXT | Japan Society for the Promotion of Science (JSPS) JP22H03003
6 · The paper itself

Abstract

Mosaic chromosomal alterations (mCAs) accumulate in the brain tissues and are associated with psychiatric disorders. The association between mCAs in circulating blood and schizophrenia (SCZ) and bipolar disorders (BD) has not been fully evaluated. We detected mCAs from blood samples in 2470 SCZ, 3732 BD, and 177,773 control subjects. The associations between mCAs and SCZ or BD were evaluated using age-adjusted logistic regression models, further evaluated in age subgroups. We analyzed the associations between high cell fraction (CF) mosaic events (CF-mCAs >5% or CF-mCAs >10%) and SCZ or BD in the same way. Furthermore, we assessed the interaction between mCAs and genetic risk scores for SCZ or BD. Autosomal mCAs, especially mosaic loss events, increased in both SCZ and BD (SCZ; OR = 1.78, P = 4.9×10

Indexed as

Bipolar DisorderSchizophreniaAdultChromosome AberrationsFemaleGenetic Predisposition to DiseaseGenetic Risk ScoreHumansMaleMosaicismRisk Factors

Identifiers

PMID41535559

What Socratic holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.