Evidence map›Paper›PMID 41535560›Full record

ArticleScientific reports2026

Evaluation of dECM hydrogel-NAP on 3D organotypic human corneal epithelium in diabetic keratopathy model.

Simona Casarella, Nicoletta Palmeri, Agata Grazia D'Amico, Assunta Virtuoso, Salvatore Saccone, Elisabetta Pricoco, Davide Scollo, Antonio Longo, Michele Papa, Francesca Boccafoschi and 2 more

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In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Simona CasarellaDepartment of Health Sciences, Università del Piemonte Orientale, Novara, 28100, Italy.
Nicoletta PalmeriSection of Anatomy, Histology and Movement Sciences, Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, 95123, Italy.
Agata Grazia D'AmicoDepartment of Drug Sciences, University of Catania, Catania, Italy.
Assunta VirtuosoDivision of Human Anatomy, Neuronal Morphology Networks & Systems Biology Lab, Department of Mental and Physical Health and Preventive Medicine, University of Campania Luigi Vanvitelli, Naples, 80138, Italy.
Salvatore SacconeDepartment of Biological, Geological and Environmental Sciences, Section of Animal Biology, University of Catania, Catania, 95123, Italy.
Elisabetta PricocoAnatomic Pathology, A.O.U. Policlinico G. Rodolico-San Marco, Catania, Italy.
Davide ScolloEye Clinic Catania University San Marco Hospital, Viale Carlo Azeglio Ciampi, Catania, 95121, Italy.
Antonio LongoDepartment of Ophthalmology, University of Catania, Catania, 95123, Italy.
Michele PapaDivision of Human Anatomy, Neuronal Morphology Networks & Systems Biology Lab, Department of Mental and Physical Health and Preventive Medicine, University of Campania Luigi Vanvitelli, Naples, 80138, Italy.
Francesca BoccafoschiDepartment of Health Sciences, Università del Piemonte Orientale, Novara, 28100, Italy.
Velia D'AgataSection of Anatomy, Histology and Movement Sciences, Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, 95123, Italy.
Grazia MaugeriSection of Anatomy, Histology and Movement Sciences, Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, 95123, Italy. graziamaugeri@unict.it.

Funding

Ministero dell'Istruzione, dell'Università e della Ricerca P2022JRBMB
6 · The paper itself

Abstract

Diabetes mellitus, a global epidemic, is a leading cause of blindness due to its detrimental effects on the retina, lens, and cornea. Diabetic keratopathy (DK), a significant ocular complication, severely compromises the corneal epithelium structure, barrier function, and healing capacity, largely driven by hyperglycemia-induced oxidative stress and apoptosis. Current therapeutic strategies for DK are limited and primarily symptomatic, failing to address underlying cellular deficits. This study investigates a novel regenerative approach utilizing a decellularized extracellular matrix (dECM) hydrogel functionalized with the neuroprotective peptide NAP (dECM hydrogel-NAP). Both dECM hydrogels and NAP have demonstrated promising regenerative and protective properties in various tissues, though their combined efficacy for diabetic corneal repair remains unexplored. Using a three-dimensional (3D) organotypic human corneal epithelium model of DK, we evaluated the therapeutic potential of dECM hydrogel-NAP to promote epithelial wound healing, restore barrier function, mitigate apoptotic responses, and support cellular viability under diabetic conditions. Our findings suggest that dECM hydrogel-NAP holds significant promise as a therapeutic strategy for supporting corneal epithelial regeneration in diabetic keratopathy.

Indexed as

Corneal DiseasesDiabetes ComplicationsEpithelium, CornealExtracellular MatrixHydrogelsApoptosisCell SurvivalHumansWound HealingHydrogels3D organotypic cultureDECM hydrogelDiabetic keratopathyNAP

Identifiers

PMID41535560
PMCPMC12881595

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.