Evidence map›Paper›PMID 41535697›Full record

ArticleScientific reports2026

Skin advanced glycation end-products do not predict pulmonary function trajectories in adults from the ILERVAS cohort.

Gerard Torres, Esther Gracia-Lavedan, Jessica González, Mario Henríquez-Beltrán, Adriano D S Targa, Maria Royo, Marcelino Bermúdez-López, Eva Castro-Boqué, José Manuel Valdivielso, Reinald Pamplona and 5 more

Abstract read
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In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Gerard TorresGroup of Translational Research in Respiratory Medicine, Institut de Recerca Biomèdica de Lleida (IRBLleida), Hospital Universitari Arnau de Vilanova i Santa Maria, Avda Alcalde Rovira Roure 80, 25198, Lleida, Spain.
Esther Gracia-LavedanGroup of Translational Research in Respiratory Medicine, Institut de Recerca Biomèdica de Lleida (IRBLleida), Hospital Universitari Arnau de Vilanova i Santa Maria, Avda Alcalde Rovira Roure 80, 25198, Lleida, Spain.
Jessica GonzálezGroup of Translational Research in Respiratory Medicine, Institut de Recerca Biomèdica de Lleida (IRBLleida), Hospital Universitari Arnau de Vilanova i Santa Maria, Avda Alcalde Rovira Roure 80, 25198, Lleida, Spain.
Mario Henríquez-BeltránGroup of Translational Research in Respiratory Medicine, Institut de Recerca Biomèdica de Lleida (IRBLleida), Hospital Universitari Arnau de Vilanova i Santa Maria, Avda Alcalde Rovira Roure 80, 25198, Lleida, Spain.
Adriano D S TargaGroup of Translational Research in Respiratory Medicine, Institut de Recerca Biomèdica de Lleida (IRBLleida), Hospital Universitari Arnau de Vilanova i Santa Maria, Avda Alcalde Rovira Roure 80, 25198, Lleida, Spain.
Maria RoyoDepartment of Internal Medicine, Hospital Universitari de Santa Maria, Lleida, Spain.
Marcelino Bermúdez-LópezVascular and Renal Translational Research Group, Institut de Recerca Biomèdica de Lleida (IRBLleida), Renal Research Network (RICORS2040, ISCIII), Lleida, Spain.
Eva Castro-BoquéVascular and Renal Translational Research Group, Institut de Recerca Biomèdica de Lleida (IRBLleida), Renal Research Network (RICORS2040, ISCIII), Lleida, Spain.
José Manuel ValdivielsoVascular and Renal Translational Research Group, Institut de Recerca Biomèdica de Lleida (IRBLleida), Renal Research Network (RICORS2040, ISCIII), Lleida, Spain.
Reinald PamplonaDepartment of Experimental Medicine, Institut de Recerca Biomèdica de Lleida (IRBLleida), University of Lleida, Lleida, Spain.
Dídac MauricioDepartment of Endocrinology and Nutrition, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
Albert LecubeCIBER Od Diabetes and Metabolic Diseases (CIBERDEM), Institute of Health Carlos III, Madrid, Spain.
Ferran BarbéGroup of Translational Research in Respiratory Medicine, Institut de Recerca Biomèdica de Lleida (IRBLleida), Hospital Universitari Arnau de Vilanova i Santa Maria, Avda Alcalde Rovira Roure 80, 25198, Lleida, Spain.
Jordi de BatlleGroup of Translational Research in Respiratory Medicine, Institut de Recerca Biomèdica de Lleida (IRBLleida), Hospital Universitari Arnau de Vilanova i Santa Maria, Avda Alcalde Rovira Roure 80, 25198, Lleida, Spain. jdebatlle@irblleida.cat.
ILERVAS team

Funding

Generalitat de Catalunya AGAUR - 2021SGR00990Instituto de Salud Carlos III CP23/00095 (Miguel Servet 2023)Instituto de Salud Carlos III FI23/00253Instituto de Salud Carlos III PI23/00237Ministerio de Ciencia, Innovación y Universidades IJC2018-037792-I; PID2023-152233OB-I00
6 · The paper itself

Abstract

Advanced glycation end-products (AGEs) activate specific receptors (RAGE) promoting inflammation and oxidative stress. The lungs, with high RAGE expression, may be particularly susceptible to AGE-related injury. This study assessed whether baseline skin AGE levels, measured by skin autofluorescence (SAF), predict pulmonary function decline in middle-aged adults with cardiovascular risk factors. This ancillary analysis of the ILERVAS cohort included adults aged 45-70 years with cardiovascular risk factors but without diabetes or chronic kidney disease. Baseline data included demographics, lifestyle, and fasting blood tests. SAF was measured using AGE Reader™, and spirometry performed at baseline and after a median follow-up of 4 years. Associations between baseline SAF and annual declines in FEV

Indexed as

Glycation End Products, AdvancedLungSkinAgedCardiovascular DiseasesCohort StudiesFemaleHumansMaleMiddle AgedRespiratory Function TestsGlycation End Products, AdvancedAdvanced glycation end-products (AGEs)Cardiovascular riskLung function declineSkin autofluorescence (SAF)

Identifiers

PMID41535697
PMCPMC12835136

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.